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Merck
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P8096

Pancreatin from porcine pancreas

meets USP testing specifications

Synonym(s):

Pancreatin from hog pancreas

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About This Item

CAS Number:
UNSPSC Code:
12352200
EC Number:
232-468-9
MDL number:
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agency

meets USP testing specifications

specific activity

1 × USP specifications

application(s)

pharmaceutical (small molecule)

storage temp.

−20°C

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Biochem/physiol Actions

Pancreatin contains enzymatic components including trypsin, amylase and lipase, ribonuclease, and protease, produced by the exocrine cells of the porcine pancreas. This combination of enzymes allows it to hydrolyze proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40°C, will digest not less than 25 times its weight of casein in 60 minutes at pH 7.5 at 40°C and will release not less than microequivalents of acid per min per mg pancreatin from olive oil at pH 9.0 at 37°C.

pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Are there any other components added to Product P8096, Pancreatin from porcine pancreas?

    Lactose is added as an extender/stabilizer.

  6. Does the product have a recommended retest date?

    If a product has a recommended retest date this would be on the Certificate of Analysis found at our website. If no recommended retest date is found on the Certificate of Analysis, then the guarantee of quality is one year from the time of delivery for unopened bottles stored at the recommended temperature. See general information on product dating in the following link to our website:  Product Dating Information Statement. Product will be retested if there is sufficient stock in the local inventory of the QC group. Customers may request a "custom" retest of material.  There will be a charge for this service.  The QC group for the product will create a quote for the service. 

  7. For which enzymatic activities is Product P8096, Pancreatin from porcine pancreas, assayed? What are the specifications for the specific activities?

    Our specification sheet at our website lists the enzymes assayed for: lipase, amylase and protease. The specifications for each activity are given.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

K E Aarak et al.
The British journal of nutrition, 110(8), 1402-1410 (2013-03-21)
In the present study, we hypothesised whether in vitro digestion of salmon oil would release different amounts of PUFA depending on the origin of the lipolytic enzymes used. For this purpose, in vitro digestion of salmon oil (SO) was performed
Zahari Vinarov et al.
Food & function, 3(11), 1206-1220 (2012-08-18)
We describe a relatively simple in vitro model for triglyceride (TG) lipolysis which mimics closely the conditions in the human stomach and small intestine. The main model advantages are: (1) as in vivo, sodium bicarbonate is used for buffering; (2)
Silvia Mazzaferro et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(3), 568-574 (2012-08-21)
In this study we investigated the potential of mucoadhesive nanoparticles to enhance the intestinal permeability of docetaxel (Dtx). These nanoparticles were composed of methyl-β-cyclodextrin (Me-β-CD) combined with poly(isobutylcyanoacrylate) and coated with thiolated chitosan. In order to encapsulate the highest amount
Jaroslaw Czubinski et al.
Journal of agricultural and food chemistry, 60(7), 1830-1836 (2012-01-24)
Lupin seed globulin proteins form complexes with flavonoids, predominantly apigenin C-glycosides. Enzymes typical for the gastrointestinal tract were used to hydrolyze lupin seed globulins. Release of native flavonoids as a result of the proteolysis reaction was observed. Different analytical methods
Mireille Andriamihaja et al.
Amino acids, 44(2), 563-572 (2012-09-12)
Utilisation of microbial enzymes may represent an alternative strategy to the use of conventional pancreatin obtained from pig pancreas for the treatment of severe pancreatic insufficiency. In this study, we focused on the capacity of two microbial preparations for their

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