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PHR1119

Supelco

D-Camphor

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
2-Camphanone, 2-Bornanone
Empirical Formula (Hill Notation):
C10H16O
CAS Number:
Molecular Weight:
152.23
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

5.24 (vs air)

vapor pressure

4 mmHg ( 70 °C)

CofA

current certificate can be downloaded

autoignition temp.

870 °F

expl. lim.

3.5 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

178-182 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to PhEur C0405000
traceable to USP 1087508

storage temp.

2-8°C

SMILES string

CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2

InChI

1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3/t7-,10+/m1/s1

InChI key

DSSYKIVIOFKYAU-XCBNKYQSSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. D-Camphor is an acyclic terpenoid and one of the key volatile constituents of essential oils of plants Artemisia tridenta, Mentha longifolia ssp., Longifolia and some Lamiaceae species.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8982 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 1

Flash Point(F)

150.8 °F

Flash Point(C)

66 °C

Certificate of Analysis

Certificate of Origin

Jeffrey N Love et al.
The Journal of emergency medicine, 27(1), 49-54 (2004-06-29)
Serious pediatric toxicity resulting from exposure to small amounts of camphor-containing products has long been a problem. Twenty years ago the United States Food and Drug Administration took several actions in an attempt to ameliorate this risk. Despite these changes
E Siegel et al.
Pediatric clinics of North America, 33(2), 375-379 (1986-04-01)
Camphor is present in several over-the-counter compounds of questionable use and therefore may be ingested by small children. Because seizures may follow ingestion of certain amounts, appropriate treatment is needed, including the use of anticonvulsants.
Gustav Georg Belz et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 10 Suppl 4, 61-67 (2003-06-17)
Independent, double-blinded, randomized, placebo-controlled studies using sublingual/oral administration of D-camphor, an extract from fresh crataegus berries, and a combination of the two (CCC) yielded the following results: Both the D-camphor and the extract from fresh crataegus berries, the components of
Weiyang Chen et al.
Molecules (Basel, Switzerland), 18(5), 5434-5454 (2013-05-15)
The fragrant camphor tree (Cinnamomum camphora) and its products, such as camphor oil, have been coveted since ancient times. Having a rich history of traditional use, it was particularly used as a fumigant during the era of the Black Death
Camphor: a chiral starting material in natural product synthesis.
T Money
Natural product reports, 2(3), 253-289 (1985-06-01)

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