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PHR1122

Supelco

Phenylethyl Alcohol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
β-PEA, 2-Phenylethyl alcohol, Benzyl carbinol, 2-Phenylethanol, PEA
Linear Formula:
C6H5CH2CH2OH
CAS Number:
Molecular Weight:
122.16
Beilstein:
1905732
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

4.21 (vs air)

vapor pressure

1 mmHg ( 58 °C)

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.5317 (lit.)

bp

219-221 °C/750 mmHg (lit.)

mp

−27 °C (lit.)

density

1.020 g/mL at 20 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1533250

storage temp.

2-30°C

SMILES string

OCCc1ccccc1

InChI

1S/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2

InChI key

WRMNZCZEMHIOCP-UHFFFAOYSA-N

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General description

Phenylethyl alcohol, is a primary aromatic alcohol of high boiling point, having a characteristic rose-like odor. It presents organoleptic properties and impacts the quality of the wine, distilled beverages, and fermented foods. It shows its presence in fresh beer and is responsible for the rose-like odor of well-ripened cheese. It is commercially and industrially an important flavor and is a component of a variety of foodstuffs such as ice cream, gelatin, candy, pudding, chewing gum, and non-alcoholic beverages. It is formed by yeasts during fermentation of alcohols either by decomposition of L-phenylalanine or metabolism of sugar substrates.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Phenylethyl alcohol may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3266 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

215.6 °F - closed cup

Flash Point(C)

102 °C - closed cup

Certificate of Analysis

Certificate of Origin

Breeding of brewing yeast producing a large amount of ?-phenylethyl alcohol and ?-phenylethyl acetate
Fukuda K, et al.
Agricultural and Biological Chemistry, 54(1), 269-271 (1990)
Phenylethyl alcohol (PEA) application slows fungal growth and maintains aroma in strawberry
Mo EK and Sung CK
Postharvest biology and technology, 45(2), 234-239 (2007)
Determination of phenylethyl alcohol by reversed-phase high-performance liquid chromatography (RP-HPLC) in Budesonide nasal spray
Hosseini R, et al.
African Journal of Pure and Applied Chemistry, 9(5), 81-90 (2015)
Simultaneous Estimation of Fluticasone propionate, Azelastine Hydrochloride, Phenylethyl alcohol and Benzalkonium chloride by RP-HPLC Method in Nasal spray preparations
Rao KLN, et al.
International Journal of Research in Pharmaceutical Sciences, 1(4), 473-480 (2010)
UV-spectrophotometric determination of beclomethasone dipropionate and phenylethyl alcohol in a nasal spray by inverse least-squares regression
Blanco M, et al.
Talanta, 50(3), 527-532 (1999)

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