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PHR1252

Procainamide hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride, 4-Aminobenzoic acid 2-diethylaminoethylamide

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About This Item

Linear Formula:
H2NC6H4CONHCH2CH2N(C2H5)2·HCl
CAS Number:
614-39-1
Molecular Weight:
271.79
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823255
EC Number:
210-381-7
Beilstein/REAXYS Number:
3729517
MDL number:
MFCD00012998

Key Documents

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Product Name

Procainamide hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H

InChI key

ABTXGJFUQRCPNH-UHFFFAOYSA-N

SMILES string

Cl.CCN(CC)CCNC(=O)c1ccc(N)cc1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. P3050000
traceable to USP 1563502

API family

procainamide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

167-169 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Procainamide hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical preparations by spectrophotometric and electrophoretic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Procainamide hydrochloride belongs to the class I of antiarrhythmic drugs and is used for the management of heart arrhythmia in cardiac patients. It is also proposed to exhibit chemoprotective behavior against cisplatin-induced kidney toxicity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC4012 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spectrophotometric determination of procainamide hydrochloride using sodium periodate
Al-Tamrah S and Al-Abbad,S
Arabian Journal of Chemistry, 8(5), 609-613 (2015)
Spectrophotometric determination of nicoumalone, acebutolol hydrochloride and procainamide hydrochloride
Sastry CSP, et al.
Talanta, 38(9), 1057-1060 (1991)
Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats
Zicca A, et al.
European Journal of Pharmacology, 442(3), 265-272 (2002)
Z Wojnarowska et al.
The Journal of chemical physics, 136(16), 164507-164507 (2012-05-09)
The pharmaceuticals, procaine hydrochloride and procainamide hydrochloride, are glass-forming as well as ionically conducting materials. We have made dielectric measurements at ambient and elevated pressures to characterize the dynamics of the ion conductivity relaxation in these pharmaceuticals, and calorimetric measurements
Malyaj Narwaley et al.
Chemical research in toxicology, 24(7), 1031-1039 (2011-06-16)
Aromatic amine drugs like aminoglutethimide (AG) and related congeners have been shown to produce phenyl radicals through metabolism by myeloperoxidase (MPO)/H(2)O(2), which has been proposed to play a role in drug-induced agranulocytosis. AG has also been shown to induce MPO
View All Related Papers

Articles

Released N-Glycan Analysis of a Therapeutic Antibody Using BIOshell™ Glycan Column

This application note describes the released N-Glycan analysis of a monoclonal antibody, cetuximab, labeled with procainamide, using a BIOshell™ Glycan HPLC column.

Quality Attribute Determination of Monoclonal Antibodies

Workflows for monoclonal antibody adalimumab characterization ensure drug safety and efficacy through critical quality attribute analysis.

Protocols

Released N-Linked Glycan Analysis Workflow of Adalimumab

A step-by-step protocol for released N-linked glycan analysis of the monoclonal antibody adalimumab, based on UHPLC-FLR-MS and procainamide labeling.

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