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PHR1284

Chlorpropamide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1-(p-Chlorobenzenesulfonyl)-3-propylurea

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About This Item

Empirical Formula (Hill Notation):
C10H13ClN2O3S
CAS Number:
94-20-2
Molecular Weight:
276.74
NACRES:
NA.24
PubChem Substance ID:
329823279
UNSPSC Code:
41116107
EC Number:
202-314-5
MDL number:
MFCD00079004

Key Documents

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InChI key

RKWGIWYCVPQPMF-UHFFFAOYSA-N

InChI

1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

SMILES string

CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C1905000, traceable to USP 1126009

API family

chlorpropamide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ABCC8(6833), KCNJ11(3767)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Chlorpropamide belongs to the sulfonylurea class of drugs and is found to be clinically effective in the treatment of Diabetes mellitus (DM). Its mode of action involves the stimulation of insulin release from the β-cells of the pancreas in response to a glucose load. It helps in increasing the number of insulin receptors, thereby enhancing the effect of insulin on the liver and promotes peripheral glucose utilization.

Application

Chlorpropamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using capillary zone elctrophoresis technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0019 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A capillary zone electrophoretic method for the determination of hypoglycemics as adulterants in herbal formulations used for the treatment of diabetes
Viana C, et al.
Analytical Methods : Advancing Methods and Applications, 5(8), 2126-2133 (2013)
Spectrophotometric Determination of Chlorpropamide in Bulk and Dosage Form by Complexation with Chloranilic Acid
Mbah JC and Okorie HN
Journal of Scientific Research, 3(1), 2126-2133 (2011)
Qing Zhu et al.
Molecular pharmaceutics, 7(4), 1291-1300 (2010-06-17)
As a result of an increase in the number of emerging therapies with dissolution limited bioavailability, formulation strategies such as solid dispersions that enhance the rate of solubilization are of interest. In this study, the microstructure of solid dispersions prepared
Yury V Seryotkin et al.
Acta crystallographica. Section B, Structural science, 69(Pt 1), 77-85 (2013-02-01)
The crystal structure of the high-pressure polymorph (α') of an antidiabetic drug, chlorpropamide [4-chloro-N-(propylaminocarbonyl)benzenesulfonamide, C(10)H(13)ClN(2)O(3)S], which is formed at ~2.8 GPa from the α-polymorph (P2(1)2(1)2(1)) on hydrostatic compression in saturated ethanol solution, has been determined. As a result of the
Terence M Williams et al.
Molecular cancer therapeutics, 11(5), 1193-1202 (2012-03-14)
There is an urgent need for the development of novel therapies to treat pancreatic cancer, which is among the most lethal of all cancers. KRAS-activating mutations, which are found in more than 90% of pancreatic adenocarcinomas, drive tumor dependency on
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