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Merck
CN

PHR1299

Pamabrom

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Pamabrom, PAM

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About This Item

CAS Number:
606-04-2
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
210-103-4

Key Documents

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InChI key

ATOTUUBRFJHZQG-UHFFFAOYSA-N

InChI

1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1077708

API family

pamabrom

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pamabrom is a weak diuretic which is used as an analgesic and an antihistamine for symptomatic control of the premenstrual syndrome. It typically assists in the reduction of bloating associated with premenstrual syndrome.

Application

Pamabrom may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0585 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sunyoung Lee et al.
The journal of physical chemistry. B, 117(31), 9233-9240 (2013-07-16)
Epithelial ovarian cancer cells enhance their ability to migrate and invade through the epithelial-mesenchymal transition (EMT), resulting in cell seeding and metastasis in the peritoneal cavity and onto adjacent organ surfaces. It has been speculated that cytoskeletal dynamics, such as
Mario I Ortiz
European journal of obstetrics, gynecology, and reproductive biology, 152(1), 73-77 (2010-05-19)
To evaluate the prevalence, impact and treatment of primary dysmenorrhea among Mexican university students. A multiple-choice questionnaire was administered to 1539 students in six university programs: medicine, nursing, nutrition, dentistry, pharmacy and psychology. Data on the presence, severity, symptoms, treatment
Rp-Lc and TLc Densitometric Determination of paracetamol and pamabrom in presence of Hazardous Impurity of paracetamol and Application to pharmaceuticals
El-Houssini OM
Analytical Chemistry Insights, 8, ACI-S12349 (2013)
Guillermo Di Girolamo et al.
Expert opinion on pharmacotherapy, 5(3), 561-570 (2004-03-12)
Primary dysmenorrhoea is the most frequent gynaecological condition, with a prevalence of 40 - 90% in women within the reproductive age. It is characterised by cyclic pelvic pain related to menstrual period, vomiting and headache. As prostaglandins and leukotrienes appear
Fixed drug eruptions and oral rechallenge.
K Kauppinen
Cleveland Clinic journal of medicine, 58(1), 64-65 (1991-01-01)
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