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Merck
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PHR1313

m-Xylene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1,3-Dimethylbenzene

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About This Item

Linear Formula:
C6H4(CH3)2
CAS Number:
108-38-3
Molecular Weight:
106.17
Beilstein:
605441
EC Number:
203-576-3
MDL number:
MFCD00008536
UNSPSC Code:
41116107
PubChem Substance ID:
329823299
NACRES:
NA.24

Key Documents

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to NIST 3004
traceable to USP 1601849

vapor density

3.7 (vs air)

CofA

current certificate can be downloaded

autoignition temp.

982 °F

expl. lim.

7 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.497 (lit.)

bp

138-139 °C (lit.)

mp

−48 °C (lit.)

density

0.868 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cc1cccc(C)c1

InChI

1S/C8H10/c1-7-4-3-5-8(2)6-7/h3-6H,1-2H3

InChI key

IVSZLXZYQVIEFR-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. m-Xylene is widely used as a residual solvent (RS) or organic volatile impurity (OVI) in pharmaceutical formulations.

Application

m-Xylene may be used as a pharmaceutical reference standard for the determination of the analyte in tablet formulations by chromatography. It can also be used as a residual solvent standard for the quantification of the analyte in tablet formulations by headspace gas chromatography (HS-GC) with flame ionization detection (FID) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3625 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

80.6 °F - closed cup

Flash Point(C)

27 °C - closed cup

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of Organic Volatile Impurities in Twenty-Three Different Coated Tablet Formulations Using Headspace Gas Chromatography with Flame Ionization Detection Technique
Latif A, et al.
Pharmaceutica Analytica Acta, 8, 553-553 (2017)
m-Xylene
USP43-NF38
United States Pharmacopeia/National Formulary, 6218-6218 (2013)
Fei Yu et al.
Journal of hazardous materials, 192(3), 1370-1379 (2011-08-13)
The purified and oxidized multi-walled carbon nanotubes (MWCNTs) with different oxygen contents are employed as adsorbents to study their physicochemical properties and adsorption behaviors of toluene, ethylbenzene and m-xylene (TEX) in aqueous solutions. The results demonstrate that adsorption capacity is
Rafael Silva-Rocha et al.
Environmental microbiology, 13(9), 2389-2402 (2011-03-18)
The regulatory and metabolic networks that rule biodegradation of pollutants by environmental bacteria are wired to the rest of the cellular physiology through both transcriptional factors and intermediary signal molecules. In this review, we examine some formalisms for describing catalytic/regulatory
Bethany Warren et al.
Environmental science & technology, 42(15), 5461-5466 (2008-08-30)
A series of m-xylene/NO(x) photooxidation experiments were conducted to determine the influence of light intensity and radiation spectrum on secondary organic aerosol (SOA) formation within the UC Riverside/CE-CERT environmental chamber. The environmental chamber is equipped with 80 115-W black lights
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