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PHR1496

Supelco

Paromomycin Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Paromomycin sulfate salt, Aminosidine sulfate
Empirical Formula (Hill Notation):
C23H45N5O14 · xH2SO4
CAS Number:
Molecular Weight:
615.63 (free base basis)
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1500003

storage temp.

-10 to -25°C

InChI

1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1

InChI key

LJRDOKAZOAKLDU-UMIPPVEZSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Paromomycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by potentiometric as well as high performance liquid chromatography (HPLC) techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3044 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Determination of salbutamol, amikacin and paromomycin sulfate by a novel sulfate polymeric membrane sensor based on 2, 6-diphenyl 4-(4-methoxyphenyl) pyrylium perchlorate.
Ganjali MR, et al.
Microchimica Acta, 149(3-4), 245-249 (2005)
Development a new method for the determination of paromomycin in trace amounts by fast Fourier continuous cyclic voltammetry at an Au microelectrode in a flowing system.
Ganjali MR, et al.
Sensors and Actuators B, Chemical, 123(2), 1125-1132 (2007)
Toshiyuki Oda et al.
Molecular biology of the cell, 26(2), 294-304 (2014-11-21)
The nexin-dynein regulatory complex (N-DRC) forms a cross-bridge between the outer doublet microtubules of the axoneme and regulates dynein motor activity in cilia/flagella. Although the molecular composition and the three-dimensional structure of N-DRC have been studied using mutant strains lacking
Alexandre Melnikov et al.
Nucleic acids research, 42(14), e112-e112 (2014-06-11)
Deep mutational scanning has emerged as a promising tool for mapping sequence-activity relationships in proteins, ribonucleic acid and deoxyribonucleic acid. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant
Suman Gupta et al.
The Journal of antimicrobial chemotherapy, 70(2), 518-527 (2014-11-13)
The objective of this study was to identify a nitroimidazo-oxazole lead molecule for the treatment of visceral leishmaniasis (VL). A library of 72 nitroimidazo-oxazoles was evaluated in vitro for their antileishmanial activity against luciferase-transfected DD8 amastigotes of Leishmania donovani. On

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