Skip to Content
Merck
CN

PHR1524

Tamsulosin hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Tamsulosin hydrochloride, (−)-(R)-5-[2-[[2-(o-ethoxy phenoxy)ethyl]amino]propyl]-2-methoxy benzene sulfonamide, monohydrochloride, TAM, 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C20H28N2O5S · HCl
CAS Number:
106463-17-6
Molecular Weight:
444.97
NACRES:
NA.24
PubChem Substance ID:
329823437
UNSPSC Code:
41116107
MDL number:
MFCD00922997

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

SMILES string

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O

InChI

1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000650, traceable to USP 1643260

API family

tamsulosin

CofA

current certificate can be downloaded

packaging

ampule of 1 × 200 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

Application

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Tamsulosin is a α1A/1D-adrenoceptor antagonist; Used as a treatment of BPH (benign prostatic hypertrophy).
Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Validated RP-HPLC and TLC methods for simultaneous estimation of tamsulosin hydrochloride and finasteride in combined dosage forms
Patel B.D and Patel J.N
Acta pharmaceutica, 60(2), 197-205 (2010)
Development and validation of stability-indicating HPTLC determination of tamsulosin in bulk and pharmaceutical dosage form
Bari.BS, et al.
Chromatography Research International, 2011(2), 197-205 (2011)
Validated stability indicating HPTLC method for the determination of Tamsulosin hydrochloride in pharmaceutical dosage forms
Choudhari.PV and Nikalje GPA
International Journal of ChemTech Research, 2(1), 646-652 (2010)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service