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PHR1580

Supelco

Lauric Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Dodecanoic acid, Lauric acid, NSC 5026
Linear Formula:
CH3(CH2)10COOH
CAS Number:
Molecular Weight:
200.32
Beilstein:
1099477
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to PhEur Y0001474
traceable to USP 1356949

storage temp.

2-30°C

SMILES string

CCCCCCCCCCCC(O)=O

InChI

1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)

InChI key

POULHZVOKOAJMA-UHFFFAOYSA-N

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General description

Lauric acid finds wide applications in cosmetics and food products. It has been tested for its use as an enhancer for topical penetration and transdermal absorption. It is used as a stabilizer for oil-in-emulsions.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Lauric acid may be used as a pharmaceutical reference standard for the determination of the analyte in biopharmaceutical formulations by chromatography techniques.

Biochem/physiol Actions

Substrate for CYP 4A11

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0576 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Dam. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

348.8 °F

Flash Point(C)

176 °C

Certificate of Analysis

Certificate of Origin

Handbook of Pharmaceutical Excipients, 28(5), 1194-1210 (2009)
Polysorbate 20 degradation in biopharmaceutical formulations: quantification of free fatty acids, characterization of particulates, and insights into the degradation mechanism
Tomlinson A, et al.
Molecular Pharmaceutics, 12(11), 3805-3815 (2015)
The degradation of polysorbates 20 and 80 and its potential impact on the stability of biotherapeutics
Kishore RSK, et al.
Pharmaceutical Research, 28(5), 1194-1210 (2011)
Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting
Zaloga J, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 101(11), 152-162 (2016)
S E Sivinski et al.
Journal of animal science and biotechnology, 11, 89-89 (2020-09-05)
While feed components capable of modulating the immune system are highly sought after and marketed, often little evidence is available to support functional immune response claims. Thus, a high-throughput in vitro cell screening system was developed to test these compounds

Protocols

GC Analysis of Free Fatty Acids in Parmesan Cheese using Nukol™ after SPME using 65 μm Carbowax/DVB Fiber

In this study, SPME was used for the analysis of free fatty acids in Parmesan cheese using a 65 μm Carbowax/divinylbenzene (DVB) SPME fiber. Headspace extraction of the cheese sample was conducted at 65 °C for 15 minutes and analyzed by GC with FID detection. SPME is ideal for analyzing the volatiles associated with solid food samples. The phase chemistry of the Nukol GC column provides excellent peak shape of acidic compounds.

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