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PHR1580

Lauric Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Dodecanoic acid, Lauric acid, NSC 5026

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About This Item

Linear Formula:
CH3(CH2)10COOH
CAS Number:
143-07-7
Molecular Weight:
200.32
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823488
EC Number:
205-582-1
Beilstein/REAXYS Number:
1099477
MDL number:
MFCD00002736

Key Documents

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Product Name

Lauric Acid, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

POULHZVOKOAJMA-UHFFFAOYSA-N

InChI

1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)

SMILES string

CCCCCCCCCCCC(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001474
traceable to USP 1356949

API family

lauric acid

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Lauric acid may be used as a pharmaceutical reference standard for the determination of the analyte in biopharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Substrate for CYP 4A11

General description

Lauric acid finds wide applications in cosmetics and food products. It has been tested for its use as an enhancer for topical penetration and transdermal absorption. It is used as a stabilizer for oil-in-emulsions.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0576 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

348.8 °F - closed cup

flash_point_c

176 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zaloga J, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 101(11), 152-162 (2016)
Handbook of Pharmaceutical Excipients, 28(5), 1194-1210 (2009)
Polysorbate 20 degradation in biopharmaceutical formulations: quantification of free fatty acids, characterization of particulates, and insights into the degradation mechanism
Tomlinson A, et al.
Molecular Pharmaceutics, 12(11), 3805-3815 (2015)
The degradation of polysorbates 20 and 80 and its potential impact on the stability of biotherapeutics
Kishore RSK, et al.
Pharmaceutical Research, 28(5), 1194-1210 (2011)
S E Sivinski et al.
Journal of animal science and biotechnology, 11, 89-89 (2020-09-05)
While feed components capable of modulating the immune system are highly sought after and marketed, often little evidence is available to support functional immune response claims. Thus, a high-throughput in vitro cell screening system was developed to test these compounds

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