CN
All Photos(1)

PHR1607

Supelco

Hydroxyzine Dihydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Hydroxyzine dihydrochloride
Empirical Formula (Hill Notation):
C21H27ClN2O2 · 2HCl
CAS Number:
Molecular Weight:
447.83
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 841
traceable to PhEur H1435000
traceable to USP 1333003

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

InChI key

ANOMHKZSQFYSBR-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Looking for similar products? Visit Product Comparison Guide

General description

Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Hydroxyzine dihydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA4723 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Sensitive and selective extractive spectrophotometric method for the determination of hydroxyzine dihydrochloride in pharmaceuticals
Rajendraprasad N, et al.
Journal of the Mexican Chemical Society, 54(4), 233-239 (2010)
A High performance liquid chromatography method for determination of hydroxyzine hydrochloride in syrup
Brand MA, et al.
Latin American Journal of Pharmacy, 30(9), 1798-1802 (2011)
Diphenylmethane antihistaminics
Drugs and Poisons in Humans: A Handbook of Practical Analysis, 315-324 (2005)
New method development for hydroxyzine determination: application in stability studies, pharmaceutical formulations, and humane serum
Sher N, et al.
Journal of Liquid Chromatography and Related Technologies, 38(8), 911-918 (2015)
Green approach towards the determination of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms.
Mumtaz A, et al.
Pakistan Journal of Pharmaceutical Sciences, 27(5), 911-918 (2014)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service