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PHR1654

Amikacin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Amikacin

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About This Item

Empirical Formula (Hill Notation):
C22H43N5O13
CAS Number:
37517-28-5
Molecular Weight:
585.60
UNSPSC Code:
41116107
EC Number:
253-538-5
NACRES:
NA.24
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur., traceable to USP 1019508

API family

amikacin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N([C@H]1[C@@H]([C@H]([C@@H]([C@H](C1)N)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CN)O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)N)O)CO)C(=O)[C@@H](O)CCN

InChI

1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1

InChI key

LKCWBDHBTVXHDL-RMDFUYIESA-N

General description

Amikacin is an aminoglycoside antibiotic. It is a semisynthetic analog of kanamycin and is effective against most gram-negative bacteria. It is used for the treatment of skin infections.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

Amikacin may be used as a pharmaceutical secondary reference standard for the determination of the analyte in plasma and milk samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB9944 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Determination of Eight Aminoglycosides in Pork Meat

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery® DSC-18 SPE and Ascentis® Express C18 UHPLC, per Chinese standards.

Determination of amikacin in human plasma by high-performance capillary electrophoresis with fluorescence detection
Oguri S and Miki Y
Journal of Chromatography. B, Biomedical Sciences and Applications, 686(2), 205-210 (1996)
Assay of amikacin in the skin by high-performance liquid chromatography
Nicoli S and Santi P
Journal of Pharmaceutical and Biomedical Analysis, 41(3), 994-997 (2006)
Amikacin serum concentrations: prediction of levels and dosage guidelines
Sarubbi FA, et al.
Annals of Internal Medicine, 89, 612-618 (1978)
View All Related Papers

Global Trade Item Number

SKUGTIN
PHR1654-1G04061834793366