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PHR2020

Candesartan Cilexetil Related Compound F

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(1-(Cyclohexyloxycarbonyloxy]ethyl 2-ethoxy-1-{[2′-(2-ethyl-2H-tetrazol-5-yl)-biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C35H38N6O6
Molecular Weight:
638.71
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1087869

API family

candesartan

CofA

current certificate can be downloaded

packaging

pkg of 20 mg

application(s)

pharmaceutical small molecule

format

neat

storage temp.

2-8°C

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Candesartan cilexetil is a selective antagonist to Angiotensin II receptors, that plays a crucial role in blood pressure regulation and sodium homeostasis, and is popularly used for the treatment of hypertension, diabetic nephropathy and congestive heart failure.

Application

Candesartan cilexetil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB4750 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simple and sensitive LC-UV method for simultaneous analysis of hydrochlorothiazide and candesartan cilexetil in pharmaceutical formulations
Qutab SS, et al.
Acta Chromatographica , 19(12), 119-119 (2007)
Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide by High-Performance Liquid Chromatography
Khedr AE
Journal of King Abdulaziz University - Medical Sciences, 15(2), 3-13 (2008)
Characterization of conjugated metabolites of a new angiotensin II receptor antagonist, candesartan cilexetil, in rats by liquid chromatography/electrospray tandem mass spectrometry following chemical derivatization
Kondo T, et al.
Journal of Mass Spectrometry : Jms, 31(8), 873-878 (1996)
Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist
Otsuka M, et al.
Thorax, 59(1), 31-38 (2004)
A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study
Lacourciere Y and Asmar R
American Journal of Hypertension, 12(12), 1181-1187 (1999)
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