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Merck
CN

PHR3029

Lomustine

pharmaceutical secondary standard, certified reference material

Synonym(s):

Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

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About This Item

Empirical Formula (Hill Notation):
C9H16ClN3O2
CAS Number:
13010-47-4
Molecular Weight:
233.70
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00012392

Key Documents

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InChI

1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

SMILES string

ClCCN(N=O)C(=O)NC1CCCCC1

InChI key

GQYIWUVLTXOXAJ-UHFFFAOYSA-N

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1369419

API family

lomustine

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

application(s)

pharmaceutical

storage temp.

2-8°C

Quality Level

300

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Lomustine can be used in quantitative determination of analyte in rat plasma using HPLC/UV) method. It can also be used as a reference standard in the determination of lomustine capsules.

Biochem/physiol Actions

Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H350

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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