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About This Item
Empirical Formula (Hill Notation):
C7H5NO3S
CAS Number:
Molecular Weight:
183.18
Beilstein:
6888
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
saccharin
manufacturer/tradename
EDQM
mp
226-229 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
O=C1NS(=O)(=O)c2ccccc12
InChI
1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChI key
CVHZOJJKTDOEJC-UHFFFAOYSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Saccharin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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R L Anderson
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(7), 637-644 (1988-07-01)
An hypothesis is presented of a mechanism for the sodium saccharin (NaS)-associated tumorigenesis of the urinary bladder that occurs in male rats. The ingestion of high doses of NaS is associated with increased urine volume and bladder mass. In rats
A G Renwick
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 23(4-5), 429-435 (1985-04-01)
Recent studies on saccharin in animals and man have allowed a detailed understanding of its fate in the body. Saccharin is slowly absorbed from the gut but rapidly eliminated in the urine, largely by renal tubular secretion. Saccharin does not
D L Arnold et al.
Toxicology, 27(3-4), 179-256 (1983-07-01)
Saccharin, first synthesized in 1879, eventually became popular as an inexpensive substitute for sugar, particularly as a non-caloric sweetner. The dispute concerning the safety of saccharin for human consumption is almost as old as saccharin itself. In this article, the
Marilyn E Carroll et al.
Behavioural pharmacology, 19(5-6), 435-460 (2008-08-12)
A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence
The toxicological effects of saccharin in short-term genotoxicity assays.
D L Arnold et al.
Mutation research, 221(2), 69-132 (1989-09-01)
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