Skip to Content
Merck
CN

SBR00026

Ligstroside

Nitric oxide inhibitor, ≥95%

Synonym(s):

(-)-ligstroside, Ligustroside

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C25H32O12
CAS Number:
35897-92-8
Molecular Weight:
524.51
UNSPSC Code:
12352200
NACRES:
NA.25

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Ligstroside, Nitric oxide inhibitor, ≥95%

InChI

1S/C25H32O12/c1-3-15-16(10-19(28)34-9-8-13-4-6-14(27)7-5-13)17(23(32)33-2)12-35-24(15)37-25-22(31)21(30)20(29)18(11-26)36-25/h3-7,12,16,18,20-22,24-27,29-31H,8-11H2,1-2H3/b15-3+/t16-,18+,20+,21-,22+,24-,25-/m0/s1

InChI key

GMQXOLRKJQWPNB-MVVLSVRYSA-N

biological source

plant

assay

≥95%

form

lyophilized powder

mol wt

524.51

solubility

DMSO: ≥10 mg/mL (19 mM)
methanol: ≥10 mg/mL

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

Quality Level

100

Application

Ligstroside is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Ligstroside is a natural product derived from leaves of Olea europaea. Ligstroside displays several potentially beneficial anti-inflammatory properties by exhibiting selective inhibition effect on COX-1 enzyme of arachidonate cascade metabolism. Ligstroside generates a reduction of the PGE2 (prostaglandin E2) levels in activated mouse macrophage (IC50 = 48.53 μM) and also reduction of the TXB2 (thromboxane B2) levels in human platelets (IC50 = 122.63 μM). Moreover, Ligstroside exhibits inhibition activity of NO production in LPS-activated RAW264.7 macrophages (17.8% at 30 μM and 40.7% at 100 μM) without any cytotoxic effect in these cells., Additionally, Ligstroside exhibits in vitro antiviral activity against parainfluenza type 3 virus (IC50 = 15.6 μM).

Features and Benefits

  • Suitable for Biochemical and Biomedical research
  • Versatile and adaptable for wide variety of laboratory and research applications

General description

Ligstroside, also known as ligusroside, is a secoiridoid glycoside, a bioactive natural compound commonly derived from plants like Ligustrum lucidum, Jasminum officinale, and Osmanthus heterophyllus. Existing research suggests that this metabolite functions as an nitric oxide inhibitor and may exhibit diverse biological activities, including anti-neoplastic, antioxidant, antiviral, and anti-inflammatory properties.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Preparation Note

Hygroscopic; store in dry place with desiccant

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000099597
0000097023

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

In vitro evaluation of secoiridoid glucosides from the fruits of Ligustrum lucidum as antiviral agents.
Ma, S.C., He, Z.D., Deng, X.L., But, P.P.H., Ooi, V.E.C., Xu, H.X., ... & Lee, S.F.
Chemical & Pharmaceutical Bulletin, 49(11), 1471-1473 (2001)
In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
Diaz, A.M., Abad, M.J., Fernandez, L., Recuero, C., Villaescusa, L., Silvan, A.M., & Bermejo, P.
Biological & Pharmaceutical Bulletin, 23(11), 1307-1313 (2000)
Chemical structures of constituents from the flowers of Osmanthus fragrans var. aurantiacus.
Liu, J., Nakamura, S., Xu, B., Matsumoto, T., Ohta, T., Fujimoto, K., ... & Matsuda, H.
Journal of Natural Medicines, 69(1), 135-141 (2015)
In African Natural Plant Products Volume II: Discoveries and Challenges in Chemistry, Health, and Nutrition.
Bai, N., He, K., Roller, M., Lai, C.S., Shao, X., Pan, M.H., & Ho, C.T.
Journal of the American Chemical Society, 2, 115-125 (2013)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service