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Merck
CN

SMB01368

Sigma-Aldrich

Octahydrocurcumin

≥95% (HPLC)

Synonym(s):

Hexahydrobisdemethoxycurcumin, Hexahydrocurcuminol, OHC

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About This Item

Empirical Formula (Hill Notation):
C21H28O6
CAS Number:
36062-07-4
Molecular Weight:
376.44
MDL number:
MFCD25371921
UNSPSC Code:
12352205
NACRES:
NA.21

Key Documents

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biological source

synthetic

Quality Level

200

Assay

≥95% (HPLC)

form

solid

storage temp.

2-8°C

SMILES string

O[C@H](C[C@@H](O)CCc2cc(c(cc2)O)OC)CCc1cc(c(cc1)O)OC

InChI

1S/C21H28O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,16-17,22-25H,3-4,7-8,13H2,1-2H3/t16-,17-/m0/s1

InChI key

OELMAFBLFOKZJD-IRXDYDNUSA-N

General description

Octahydrocurcumin (OHC) is an active metabolite of curcumin. OHC has shown anti-inflammatory activity and antioxidant effects on LPS-stimulated inflammation through inhibition of the NF-κB signaling pathway.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000208990
0000208991
0000187143
0000208990
0000208991

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Zhen-Biao Zhang et al.
Frontiers in pharmacology, 9, 1181-1181 (2018-11-06)
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of
Qing-Feng Xie et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 8856135-8856135 (2021-01-12)
Curcumin (CUR) possesses pronounced anti-inflammatory and antioxidant activities. Generally, the clinical application of CUR is restricted due to its apparent unstability and poor absorption, and the biological activities of CUR may be closely associated with its metabolites. Tetrahydrocurcumin (THC) and

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