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Merck
CN

SMB01368

Octahydrocurcumin

≥95% (HPLC)

Synonym(s):

Hexahydrobisdemethoxycurcumin, Hexahydrocurcuminol, OHC

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About This Item

Empirical Formula (Hill Notation):
C21H28O6
CAS Number:
Molecular Weight:
376.44
UNSPSC Code:
12352205
NACRES:
NA.21
MDL number:
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biological source

synthetic

Quality Level

assay

≥95% (HPLC)

form

solid

storage temp.

2-8°C

SMILES string

O[C@H](C[C@@H](O)CCc2cc(c(cc2)O)OC)CCc1cc(c(cc1)O)OC

InChI

1S/C21H28O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,16-17,22-25H,3-4,7-8,13H2,1-2H3/t16-,17-/m0/s1

InChI key

OELMAFBLFOKZJD-IRXDYDNUSA-N

General description

Octahydrocurcumin (OHC) is an active metabolite of curcumin. OHC has shown anti-inflammatory activity and antioxidant effects on LPS-stimulated inflammation through inhibition of the NF-κB signaling pathway.


Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Zhen-Biao Zhang et al.
Frontiers in pharmacology, 9, 1181-1181 (2018-11-06)
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of
Qing-Feng Xie et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 8856135-8856135 (2021-01-12)
Curcumin (CUR) possesses pronounced anti-inflammatory and antioxidant activities. Generally, the clinical application of CUR is restricted due to its apparent unstability and poor absorption, and the biological activities of CUR may be closely associated with its metabolites. Tetrahydrocurcumin (THC) and



Global Trade Item Number

SKUGTIN
SMB01368-25MG04065268876985
SMB01368-5MG04065268876992