6-Hydroxydaidzein

6-Hydroxydaidzein, also known as 4′,6,7-trihydroxyisoflavone, is a hydroxylated derivative of daidzein, distinguished by an additional hydroxyl group at the 6th position. It belongs to the class of organic compounds called isoflavones, which are polycyclic structures featuring a 2-isoflavene core and a ketone group at the C4 carbon. This composition classifies 6-hydroxydaidzein as a flavonoid.

This compound has been detected in foods such as soybeans (Glycine max) and various pulses, suggesting its potential as a biomarker for the consumption of these plant-based products. As a primary metabolite, 6-hydroxydaidzein plays a vital role in an organism′s growth, development, and reproduction. Numerous studies have highlighted its pharmacological properties, including tyrosinase inhibition, anti-cancer activity, anti-obesity effects, and cognitive enhancement.

Current research has demonstrated that 6-hydroxydaidzein may inhibit enzyme activities and critical signaling pathways, although this effect may be reversed by coumarin derivatives. Research utilizing in vitro assays and molecular docking has also investigated its potential impact on antibiotic-resistant bacterial strains. Functionally, 6-hydroxydaidzein serves multiple roles, including acting as a PPARalpha and PPARgamma agonist, an anti-inflammatory agent, an antimutagen, and a tyrosinase inhibitor.

6-hydroxydaidzein finds application in metabolomics, biochemical and life science related research.

Versatile and adaptable for wide variety of research and metabolomics applications.