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About This Item
Empirical Formula (Hill Notation):
C12H18N2O3S
CAS Number:
Molecular Weight:
270.35
Beilstein:
1984428
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
tolbutamide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI
1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChI key
JLRGJRBPOGGCBT-UHFFFAOYSA-N
Gene Information
human ... ABCC8(6833), KCNJ11(3767)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Tolbutamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Anti-diabetic agent. Metabolized by CYP2C9 (tolbutamide hydroxylase).
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Ning Wang et al.
ACS nano, 9(3), 3159-3168 (2015-03-12)
Cytochromes P450 (CYPs) enzymes are involved in catalyzing the metabolism of various endogenous and exogenous compounds. A rapid analysis of drug metabolism reactions by CYPs is required because they can metabolize 95% of current drugs in drug development and effective
Paulette B Goforth et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11405-11415 (2014-08-22)
The adipocyte-derived hormone leptin modulates neural systems appropriately for the status of body energy stores. Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also known as hypocretin)-producing neurons, which control feeding, activity, and energy expenditure, among other parameters. Our previous
Arian F Baquero et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 9982-9994 (2014-07-25)
Leptin is well known for its role in the regulation of energy homeostasis in adults, a mechanism that at least partially results from the inhibition of the activity of NPY/AgRP/GABA neurons (NAG) in the arcuate nucleus of the hypothalamus (ARH).
Xiwei Zheng et al.
Journal of chromatography. A, 1371, 82-89 (2014-12-03)
Ultrafast affinity extraction and a multi-dimensional affinity system were developed for measuring free drug fractions at therapeutic levels. This approach was used to compare the free fractions and global affinity constants of several sulfonylurea drugs in the presence of normal
Zhiping Lin et al.
Die Pharmazie, 69(7), 537-541 (2014-07-31)
To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo. Scutellarin and saline were intravenously administered to male Wistar rats via the caudal vein for 7 days consecutively. On the 8th
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