T7891
Thiochrome
analytical standard
Synonym(s):
2,7-Dimethylthiachromine-8-ethanol
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About This Item
Empirical Formula (Hill Notation):
C12H14N4OS
CAS Number:
Molecular Weight:
262.33
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
analytical standard
Quality Level
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
Cc1ncc2CN3C(C)=C(CCO)SC3=Nc2n1
InChI
1S/C12H14N4OS/c1-7-10(3-4-17)18-12-15-11-9(6-16(7)12)5-13-8(2)14-11/h5,17H,3-4,6H2,1-2H3
InChI key
GTQXMAIXVFLYKF-UHFFFAOYSA-N
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Selective M4 muscarinic receptor enhancer of acetylcholine affinity.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Nathalie Mangel et al.
Journal of experimental botany, 68(13), 3351-3363 (2017-09-02)
Vitamin B1, which consists of the vitamers thiamin and its phosphorylated derivatives, is an essential micronutrient for all living organisms because it is required as a metabolic cofactor in several enzymatic reactions. Genetic diversity of vitamin B1 biosynthesis and accumulation
Zubair Anwar et al.
Journal of photochemistry and photobiology. B, Biology, 203, 111766-111766 (2020-01-14)
The photolysis of thiochrome (THC), an oxidation product of thiamine (vitamin B1) (THE), used for its fluorimetric assay, has been studied in the pH range 7.0-12.0. THC undergoes photooxidation to oxodihydrothiochrome (ODTHC) which is oxidized to a non-fluorescent compound (OP1)
S Lazareno et al.
Molecular pharmacology, 65(1), 257-266 (2004-01-15)
Thiochrome (2,7-dimethyl-5H-thiachromine-8-ethanol), an oxidation product and metabolite of thiamine, has little effect on the equilibrium binding of l-[3H]N-methyl scopolamine ([3H]NMS) to the five human muscarinic receptor subtypes (M1-M5) at concentrations up to 0.3 mM. In contrast, it inhibits [3H]NMS dissociation
Roberta Leonardi et al.
The Journal of biological chemistry, 279(17), 17054-17062 (2004-02-06)
The biosynthesis of thiamine in Escherichia coli requires the formation of an intermediate thiazole from tyrosine, 1-deoxy-d-xylulose-5-phosphate (Dxp), and cysteine using at least six structural proteins, ThiFSGH, IscS, and ThiI. We describe for the first time the reconstitution of thiazole
N G Melnichenko et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 51(4-5), 389-391 (1999-08-13)
The horse-radish peroxidase catalyzes oxidation of thiamine in vitro in presence of hydroperoxide hydrogen (H2O2) and olenic acid (LOOH) (as an emultion) with formation of thiochrome (2,7-dimethyl-8-(oxyetyl-5,6-dihydrothiazolo (2,3-a) pyrimido (4,5-d) pyrimidine, oxodihydrothiochrome (2,7dimethyl-oxo-8-(-2-oxo-ethyl)-5,6,9a, 10-tetrahydrothiazolo (2,3-a) pyrimido (4,5-d) pyrimidine and thiamine
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