T9765
Todralazine hydrochloride
analytical standard
Synonym(s):
Ecarazine
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About This Item
Empirical Formula (Hill Notation):
C11H12N4O2 · HCl
CAS Number:
Molecular Weight:
268.70
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
SMILES string
Cl.CCOC(=O)NNc1nncc2ccccc12
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Antihypertensive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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K Gasiorowski et al.
Mutagenesis, 12(6), 411-415 (1997-12-31)
Todralazine, an antihypertensive drug of the hydrazinoph-thalazine group, markedly decreased the mutagenic activity of potassium dichromate in standard bacterial tests. At the highest todralazine dose tested inhibition of potassium dichromate mutagenic activity by approximately 90% in the Ames test and
Y Dohi et al.
Hypertension (Dallas, Tex. : 1979), 28(1), 58-63 (1996-07-01)
We studied the effects of long-term antihypertensive treatment on endothelial function in renal resistance arteries from spontaneously hypertensive rats (SHR). Wistar-Kyoto rats (WKY) were used as a normotensive reference. Adult SHR were treated with benidipine (a calcium antagonist) or ecarazine
K Markiewicz et al.
Acta medica Hungarica, 42(3-4), 153-162 (1985-01-01)
The study involved 13 patients with primary hypertension who exercised on a bicycle ergometer with intensity increasing up to submaximum level. The exercise was carried out in four stages: before treatment (1st study), following one week treatment with 50 mg
K Gasiorowski et al.
Mutation research, 324(3), 133-137 (1994-07-01)
Todralazine decreased the mutagenic activity of tested direct- and indirect-acting mutagens. Despite the marked differences between efficient todralazine doses (ED50) it was observed that, in the case of tested indirect mutagens as well as in some of the direct mutagens
Z Jastrzebski et al.
Acta poloniae pharmaceutica, 50(4-5), 327-330 (1993-01-01)
Acute intravenous toxicity and antihypertensive activity of KB1, a novel todralazine analog was investigated and compared with the effects of todralazine (Td) in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. LD50 values were 72 mg.kg-1 for KB1, and 255
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