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Merck
CN

T9765

Supelco

Todralazine hydrochloride

analytical standard

Synonym(s):

Ecarazine

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About This Item

Empirical Formula (Hill Notation):
C11H12N4O2 · HCl
CAS Number:
3778-76-5
Molecular Weight:
268.70
MDL number:
MFCD00057321
UNSPSC Code:
41116107
PubChem Substance ID:
24900601

Key Documents

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grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CCOC(=O)NNc1nncc2ccccc12

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Antihypertensive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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K Gasiorowski et al.
Polish journal of occupational medicine and environmental health, 6(4), 383-389 (1993-01-01)
Hydralazine, dihydralazine and todralazine were tested in the aspect of their mutagenic potency, and the influence upon the mutagenicity of standard promutagen--B(a)P. Hydralazine exhibited strong mutagenic activity in the Ames test while mutagenic activity of dihydralazine was relatively weak. Todralazine
M Drózdz et al.
Clinical physiology and biochemistry, 7(2), 97-100 (1989-01-01)
Fibroblast cultures exposed to the drugs inducing a collagen-like syndrome (hydralazine and binazine) displayed growth inhibition and decrease in cellular protein content in a dose-dependent manner compared with control cultures. This was accompanied by the inhibitory effect of the drugs
Z Gomez de Balugera et al.
Journal of pharmaceutical and biomedical analysis, 12(7), 883-887 (1994-07-01)
Differential pulse polarography (DPP) is proposed as a direct method for the quantitation of todralazine and acetazolamide in human serum. The method was applied to the determination of these drugs in human serum, after a liquid-liquid extraction process. This extraction
B Chłopkiewicz
Acta poloniae pharmaceutica, 53(5), 361-364 (1996-09-01)
The genotoxicity of antihypertensive drugs, hydralazine, dihydralazine and binazine was assessed on the base of their capacity to induce micronuclei in L929 cell line. In our previous investigations we indicated that these drugs did not induce micronuclei in bone marrow
M Gajewska et al.
Acta poloniae pharmaceutica, 52(1), 1-4 (1995-01-01)
Suitability of four arylosulfonic acids and their sodium salts to form derivatives with hypotensive drugs were studied. New crystalline arylosulfonates of todralazine, hydralazine and dihydralazine were obtained. Physico-chemical properties of the obtained arylosulfonates were tested. Reagents mentioned above were also
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