T9765
Todralazine hydrochloride
analytical standard
Synonym(s):
Ecarazine
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About This Item
Empirical Formula (Hill Notation):
C11H12N4O2 · HCl
CAS Number:
Molecular Weight:
268.70
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
Cl.CCOC(=O)NNc1nncc2ccccc12
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Antihypertensive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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K Gasiorowski et al.
International journal of occupational medicine and environmental health, 7(4), 371-378 (1994-01-01)
Todralazine markedly reduced the mutagenic activity of the standard direct-acting mutagen--daunorobicine (DRC)--in the Ames test. Spectrophotometric measurements proved that todralazine did not interact with DRC in water solution. Todralazine neither interacted with calf thymus DNS in vitro, nor changed the
K Gasiorowski et al.
Mutagenesis, 12(6), 411-415 (1997-12-31)
Todralazine, an antihypertensive drug of the hydrazinoph-thalazine group, markedly decreased the mutagenic activity of potassium dichromate in standard bacterial tests. At the highest todralazine dose tested inhibition of potassium dichromate mutagenic activity by approximately 90% in the Ames test and
A Karasawa et al.
Journal of pharmacobio-dynamics, 5(11), 930-935 (1982-11-01)
In order to examine clinical potential for ecarazine, prazosin, phentolamine and hexamethonium to cause orthostatic hypotension in man, the effects of these drugs on the vasopressor reflexes induced by bilateral carotid artery occlusion (BCO) or head-up tilting (Tilt) have been