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Y0000033

Carbamazepine impurity A

Name: Carbamazepine impurity A
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):

10,11-Dihydrocarbamazepine, 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide

Empirical Formula (Hill Notation):

C₁₅H₁₄N₂O

CAS Number:

3564-73-6

Molecular Weight:

238.28

MDL number:

MFCD00005072

PubChem Substance ID:

329830822

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

carbamazepine

manufacturer/tradename

EDQM

mp

205-210 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NC(=O)N1c2ccccc2CCc3ccccc13

InChI

1S/C15H14N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-8H,9-10H2,(H2,16,18)

InChI key

PHNLCHMJDSSPDQ-UHFFFAOYSA-N

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Analytical Reference Standards

Sigma-Aldrich

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Carbamazepine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Signal Word

Danger

Hazard Statements

H302 - H317 - H336 - H360D

Precautionary Statements

P201 - P280 - P301 + P312 + P330 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A - Skin Sens. 1A - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor.

M G Bixel et al.

European journal of biochemistry, 267(1), 110-120 (1999-12-22)

Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the structure of PhTXs and poly(methylene tetramine)s on the binding affinity have been investigated. Using the

An orthorhombic polymorph of 10,11-dihydrocarbamazepine.

William T A Harrison et al.

Acta crystallographica. Section C, Crystal structure communications, 62(Pt 5), o240-o242 (2006-05-09)

The title compound (systematic name: 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide), C15H14N2O, is shown to crystallize as an orthorhombic polymorph to complement the known monoclinic form. The molecular conformations of both forms are very similar, involving a bent conformation for the seven-membered azepine ring and

Liquid chromatographic methods for assay of carbamazepine, 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and tablets.

T D Cyr et al.

Journal - Association of Official Analytical Chemists, 70(5), 836-840 (1987-09-01)

Liquid chromatographic (LC) methods have been developed for the determination of carbamazepine, the impurity 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and tablets. The LC methods specify a 5 micron diol column and a mobile phase of acetonitrile-methanol-0.05% aqueous

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