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Y0000359

Acebutolol impurity B

Name: Acebutolol impurity B
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide, Diacetolol

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₄N₂O₄

CAS Number:

22568-64-5

Molecular Weight:

308.37

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical primary standard

API family

acebutolol

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N(C(C)C)CC(O)COc1c(cc(cc1)NC(=O)C)C(=O)C

InChI

1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)

InChI key

AWOGXJOBNAWQSF-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Effect of adjuvant arthritis on the disposition of acebutolol enantiomers in rats.

M Piquette-Miller et al.

Agents and actions, 37(3-4), 290-296 (1992-11-01)

Disease states such as arthritis may interact with the kinetics of beta-blockers. Acebutolol (AC) is a chiral beta-blocker which is available as a racemate. The beneficial properties of AC, however, is attributed mainly to the S-(+)-enantiomer. The disposition of AC

Comparison of beta-adrenoceptor selectivity of acebutolol and its metabolite diacetolol with metoprolol and propranolol in normal man.

M S Thomas et al.

European journal of clinical pharmacology, 29(6), 679-683 (1986-01-01)

The beta-adrenergic selectivity of diacetolol, the major metabolite of acebutolol, has been compared with that of acebutolol, metoprolol and propranolol in 11 normal subjects. Bronchial and cardiac beta-adrenoceptor blockade were assessed on separate occasions after diacetolol 600 mg, acebutolol 400

Pharmacologic properties of acebutolol: relationship of hydrophilicity to central nervous system penetration.

D R Abernethy et al.

American heart journal, 109(5 Pt 2), 1120-1125 (1985-05-01)

Studies in various animal models have shown acebutolol to be a relatively cardioselective beta-adrenoceptor-blocking agent possessing both partial agonist and membrane-stabilizing activities. The latter property may not be significant at clinically used doses. Acebutolol has both antihypertensive and antiarrhythmic effects.

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Global Trade Item Number

SKU	GTIN
Y0000359	04061833816370