Y0000359
Acebutolol impurity B
European Pharmacopoeia (EP) Reference Standard
Synonym(s):
N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide, Diacetolol
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About This Item
Empirical Formula (Hill Notation):
C16H24N2O4
CAS Number:
Molecular Weight:
308.37
UNSPSC Code:
41116107
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
acebutolol
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
N(C(C)C)CC(O)COc1c(cc(cc1)NC(=O)C)C(=O)C
InChI
1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)
InChI key
AWOGXJOBNAWQSF-UHFFFAOYSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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M Piquette-Miller et al.
Agents and actions, 37(3-4), 290-296 (1992-11-01)
Disease states such as arthritis may interact with the kinetics of beta-blockers. Acebutolol (AC) is a chiral beta-blocker which is available as a racemate. The beneficial properties of AC, however, is attributed mainly to the S-(+)-enantiomer. The disposition of AC
D R Abernethy et al.
American heart journal, 109(5 Pt 2), 1120-1125 (1985-05-01)
Studies in various animal models have shown acebutolol to be a relatively cardioselective beta-adrenoceptor-blocking agent possessing both partial agonist and membrane-stabilizing activities. The latter property may not be significant at clinically used doses. Acebutolol has both antihypertensive and antiarrhythmic effects.
M S Thomas et al.
European journal of clinical pharmacology, 29(6), 679-683 (1986-01-01)
The beta-adrenergic selectivity of diacetolol, the major metabolite of acebutolol, has been compared with that of acebutolol, metoprolol and propranolol in 11 normal subjects. Bronchial and cardiac beta-adrenoceptor blockade were assessed on separate occasions after diacetolol 600 mg, acebutolol 400
M Piquette-Miller et al.
Journal of clinical pharmacology, 32(2), 148-156 (1992-02-01)
Acebutolol (AC) is a chiral beta-blocker that is metabolized to an equipotent chiral metabolite, diacetolol (DC). A stereoselective disposition of AC and DC enantiomers has recently been reported in young healthy subjects. As many physiologic properties affecting drug disposition are
U Borchard et al.
Archives internationales de pharmacodynamie et de therapie, 273(1), 4-17 (1985-01-01)
The cardioselectivity and specificity of diacetolol, the major metabolite of the beta-adrenoceptor blocking drug acebutolol, was studied in the isolated right atrium of the guinea-pig and rat and the papillary muscle and trachea of the guinea-pig. The beta-adrenoceptor blocking potency
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