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Merck
CN

Y0000537

Emedastine difumarate

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C25H34N4O9
CAS Number:
87233-62-3
Molecular Weight:
534.56
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

emedastine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N1(CCN(CCC1)c2[n](c3c(n2)cccc3)CCOCC)C.OC(=O)\C=C\C(=O)O.OC(=O)\C=C\C(=O)O

InChI

1S/C17H26N4O.2C4H4O4/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-19(2)11-12-20;2*5-3(6)1-2-4(7)8/h4-5,7-8H,3,6,9-14H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+

InChI key

FWLKKPKZQYVAFR-LVEZLNDCSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Emedastine difumarate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Annemiek Vermeeren et al.
Journal of psychopharmacology (Oxford, England), 16(1), 57-64 (2002-04-13)
Emedastine is registered in its country of origin (Japan) as an antihistamine for the indication of seasonal allergic rhinitis. Further research on the drug's sedating properties was needed to secure its registration elsewhere. The present study was designed to compare
V Orfeo et al.
European journal of ophthalmology, 12(4), 262-266 (2002-09-11)
To assess the efficacy of nedocromil sodium 2% eye drops and emedastine difumarate 0.05% eye drops in controlling the ocular allergic reaction induced by conjunctival allergen challenge (CAC). Thirty subjects with a personal history of allergic conjunctivitis were enrolled (first
M Brunner et al.
Xenobiotica; the fate of foreign compounds in biological systems, 32(9), 761-770 (2002-10-25)
1. In a mass balance study, six healthy male volunteers received a single oral dose of 4 mg (14)C-labelled emedastine difumarate. The pharmacokinetics of the total radioactivity and unchanged drug were assessed over 48 h. Urinary and faecal excretion were
Shoichi Harada et al.
Journal of pharmaceutical sciences, 94(1), 17-24 (2005-03-12)
Antihistamine effects of emedastine applied topically with three vehicles varying in their polarities were investigated in rats. The pharmacological effect of emedastine differed greatly depending on its concentration, treatment time, and vehicle. The antihistamine effect reached a plateau after approximately
Mario E Corrado et al.
Arzneimittel-Forschung, 54(10), 660-665 (2004-11-24)
Emedastine is a new H1-receptor antagonist endowed with potent and selective antihistamine activity. The aim of this study was to evaluate the therapeutic efficacy and tolerability of emedastine difumarate (CAS 87233-62-3) in Caucasian patients in the treatment of seasonal allergic
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