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Merck
CN

Y0000538

Dexamethasone isonicotinate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dexamethasone 21-isonicotinate

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About This Item

Empirical Formula (Hill Notation):
C28H32FNO6
CAS Number:
2265-64-7
Molecular Weight:
497.56
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

dexamethasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

F[C@@]21[C@H]([C@H]4[C@@]([C@@]([C@@H](C4)C)(O)C(=O)COC(=O)c5ccncc5)(C[C@@H]2O)C)CCC3=CC(=O)C=C[C@@]31C

InChI

1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1

InChI key

BQTXJHAJMDGOFI-NJLPOHDGSA-N

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone isonicotinate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Regulatory Information

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G Hochhaus et al.
Journal of pharmaceutical and biomedical analysis, 9(9), 761-767 (1991-01-01)
A combined LC/RIA procedure is described for the selective determination of dexamethasone (DEX) and its prodrug dexamethasone-21-isonicotinate (DIN) in plasma. The low affinity of the employed dexamethasone antiserum for DIN (cross-reactivity less than 0.5%) allowed the direct determination of DEX
Ersilia Pappalardo et al.
Veterinary dermatology, 13(6), 331-336 (2002-12-05)
A 7-year-old-female goat was referred with a 3-month history of chronic dermatitis, which partially responded to combined corticosteroid and antibiotic therapy. At dermatological examination diffuse alopecia, pustules and crusts were observed on the head, neck, dorsum and perianal area. Dermatophyte
Laurent L Couëtil et al.
Journal of veterinary internal medicine, 20(2), 399-406 (2006-04-06)
Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of inflammatory gene expression via inhibition of transcription factors such as
P L Toutain et al.
American journal of veterinary research, 45(9), 1750-1756 (1984-09-01)
Pharmacokinetics of dexamethasone and prednisolone were studied in 6 horses given dexamethasone alcohol (IV or IM) or dexamethasone 21-isonicotinate as a solution IV or IM (50 micrograms/kg of body weight), prednisolone 21-sodium succinate IV or IM (0.6 mg/kg of body
[Vorenicol and Bisolvon: advice].
J F Nouws
Tijdschrift voor diergeneeskunde, 106(22), 1166-1168 (1981-11-15)
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