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About This Item
Empirical Formula (Hill Notation):
C22H32N2O2 · 2HCl
CAS Number:
Molecular Weight:
429.42
UNSPSC Code:
41116107
NACRES:
NA.24
SMILES string
[Cl-].[Cl-].N(CCCCCCNCCc2ccccc2)CCc1cc(c(cc1)O)O.[H+].[H+]
InChI
1S/C22H32N2O2.2ClH/c25-21-11-10-20(18-22(21)26)13-17-24-15-7-2-1-6-14-23-16-12-19-8-4-3-5-9-19;;/h3-5,8-11,18,23-26H,1-2,6-7,12-17H2;2*1H
InChI key
VPDULUNRSQWWJB-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
dopexamine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Dopexamine dihydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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Jurgen Birnbaum et al.
Critical care (London, England), 10(4), R117-R117 (2006-08-09)
The administration of dopexamine may constitute a therapeutical option to improve hepatosplanchnic perfusion in sepsis. In order to verify this hypothesis, we administered dopexamine in an experimental sepsis model in rats. This prospective, randomized, controlled laboratory study was conducted in
Rupert M Pearse et al.
Critical care medicine, 36(4), 1323-1329 (2008-04-02)
To establish whether perioperative low-dose dopexamine infusion (< or = 1 microg/kg/min) is associated with a reduction in mortality and duration of hospital stay following major surgery. Medline, EMBASE, CINAHL, Cochrane Library, Google Scholar, and reference lists. Two reviewers independently
Meta-analyses of the effects of dopexamine in major surgery: do all roads lead to Rome?
J J Pandit
Anaesthesia, 64(6), 585-588 (2009-05-21)
Shaman Jhanji et al.
Critical care (London, England), 14(4), R151-R151 (2010-08-12)
Post-operative outcomes may be improved by the use of flow related end-points for intra-venous fluid and/or low dose inotropic therapy. The mechanisms underlying this benefit remain uncertain. The objective of this study was to assess the effects of stroke volume
Philippe Seguin et al.
Critical care (London, England), 10(1), R32-R32 (2006-03-02)
Microcirculatory blood flow, and notably gut perfusion, is important in the development of multiple organ failure in septic shock. We compared the effects of dopexamine and norepinephrine (noradrenaline) with those of epinephrine (adrenaline) on gastric mucosal blood flow (GMBF) in
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