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Merck
CN

Y0000798

Pholcodine for peak identification

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Pholcodine

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About This Item

Empirical Formula (Hill Notation):
C23H30N2O4
CAS Number:
509-67-1
Molecular Weight:
398.50
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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SMILES string

N6(CCOCC6)CCOc1c2c3c(cc1)C[C@H]4N(CC[C@]53[C@@H](O2)[C@H](C=CC54)O)C

InChI

1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16?,17-,18+,22+,23+/m1/s1

InChI key

GPFAJKDEDBRFOS-SLITUTQKSA-N

grade

pharmaceutical primary standard

API family

pholcodine

manufacturer/tradename

EDQM

drug control

kontrollierte Droge in Deutschland, regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal); Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Pholcodine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Allergy to pholcodine: first case documented by oral challenge.
F Codreanu et al.
Allergy, 60(4), 544-545 (2005-02-25)
Didier G Ebo et al.
Anesthesiology, 107(2), 253-259 (2007-08-02)
Diagnosis of allergy from neuromuscular blocking agents is not always straightforward. The objectives of the current study were to investigate the value of quantification of immunoglobulin E (IgE) by ImmunoCAP (Phadia AB, Uppsala, Sweden) in the diagnosis of rocuronium allergy
IgE-mediated anaphylactic reactions to neuromuscular blocking agents: can they be prevented?
E Florvaag et al.
Current allergy and asthma reports, 8(5), 375-376 (2008-08-07)
E Florvaag et al.
Allergy, 61(1), 49-55 (2005-12-21)
A previous study showed a relation between pholcodine (PHO) consumption, prevalence of IgE-sensitization to PHO, morphine (MOR) and suxamethonium (SUX) and anaphylaxis to neuromuscular blocking agents (NMBA). The purpose of this pilot study was to explore the effect on IgE
Z Kovács et al.
Analytical and bioanalytical chemistry, 386(6), 1709-1716 (2006-09-28)
The acid-base properties of pholcodine, a cough-depressant agent, and related compounds including metabolites were studied by 1H NMR-pH titrations, and are characterised in terms of macroscopic and microscopic protonation constants. New N-methylated derivatives were also synthesized in order to quantitate
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