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Merck
CN

Y0000822

Molsidomine impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Nitrosomorpholine, NMOR

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About This Item

Empirical Formula (Hill Notation):
C4H8N2O2
CAS Number:
Molecular Weight:
116.12
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI

1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2

SMILES string

O=NN1CCOCC1

InChI key

ZKXDGKXYMTYWTB-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

molsidomine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. For further information and support, including certificate/ product information sheets, please go to the website of the issuing Pharmacopoeia.

Application

Molsidomine impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

target_organs

Liver

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Muta. 2 - STOT RE 1


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Lei Song et al.
Scientific reports, 10(1), 8329-8329 (2020-05-21)
The gloomy outcome of liver cancer is mainly due to the high rates of metastasis and recurrence, even after curative resection for early stage liver cancer. Our study was conducted to find the animal model suitable for the study of
Suramya Waidyanatha et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(11), 1341-1351 (2020-06-06)
The specialty amine catalyst 2,2'-dimorpholinodiethyl ether (DMDEE) is a high-production volume chemical used in the production of flexible foam, high-resilient molded foam, and in coatings and adhesives. The disposition and metabolism of [14C]DMDEE (20 or 200 mg/kg) were determined in male
Brandi Patrice Smith et al.
Scientific reports, 10(1), 19128-19128 (2020-11-07)
Screening agrochemicals and pharmaceuticals for potential liver toxicity is required for regulatory approval and is an expensive and time-consuming process. The identification and utilization of early exposure gene signatures and robust predictive models in regulatory toxicity testing has the potential
Hekap Kim et al.
Environmental health and toxicology, 26, e2011003-e2011003 (2011-11-30)
N-Nitrosodimethylamine (NDMA) is classified as a probable human carcinogen by the United States Environmental Protection Agency (US EPA) and is formed during the chlorination of municipal drinking water. In this study, selected nitrosamines were measured in chlorinated drinking water collected
Hitoshi Kodamatani et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(11), 1393-1399 (2020-07-28)
An ultra-sensitive analytical system that can determine the concentration of N-nitrosamines at the ng/L level without preconcentration was used to investigate the contamination, decomposition, and formation of N-nitrosodimethylamine (NDMA) and other N-nitrosamines in water samples during general analytical procedures. A

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