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Merck
CN

21177

Calcium phosphate dibasic

puriss. p.a., anhydrous, >98.5% (KT)

Synonym(s):

Calcium hydrogen phosphate

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About This Item

Linear Formula:
CaHPO4
CAS Number:
Molecular Weight:
136.06
UNSPSC Code:
12352300
PubChem Substance ID:
EC Number:
231-826-1
MDL number:
Assay:
>98.5% (KT)
Form:
powder
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InChI key

FUFJGUQYACFECW-UHFFFAOYSA-L

InChI

1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2

SMILES string

[Ca++].OP([O-])([O-])=O

grade

puriss. p.a.

assay

>98.5% (KT)

form

powder

impurities

≤0.2% insoluble matter in HCl

loss

6.5-8.5% loss on ignition, 850 °C

anion traces

chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤1000 mg/kg

cation traces

As: ≤0.5 mg/kg, Ba: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤200 mg/kg, K: ≤50 mg/kg, Mg: ≤2000 mg/kg, Mn: ≤100 mg/kg, Na: ≤500 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤200 mg/kg, Zn: ≤5 mg/kg

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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J L Greger et al.
The Journal of nutrition, 117(4), 717-724 (1987-04-01)
The effects of commercially available calcium supplements and milk on tissue levels and apparent absorption of calcium, magnesium, phosphorus, zinc, iron and copper were evaluated in two studies with rats. Calcium supplements (calcium phosphate dibasic, oyster shell preparations with and
Yves Roggo et al.
Journal of pharmaceutical and biomedical analysis, 179, 112971-112971 (2019-11-28)
Continuous Manufacturing (CM) of pharmaceutical drug products is a rather new approach within the pharmaceutical industry. In the presented paper, a GMP continuous wet granulation line used for clinical production of solid dosage forms was investigated with a thorough monitoring
Victoria Pauli et al.
Journal of pharmaceutical sciences, 108(6), 2041-2055 (2019-01-25)
In line with the ongoing shift from batch to continuous pharmaceutical production of solid oral dosage forms, a novel continuous fluid-bed dryer was developed. The forced feed nature of the Glatt GPCG2 CM fluid-bed dryer allows continuous, first-in-first-out drying of
Fernando Notario-Pérez et al.
Carbohydrate polymers, 179, 305-316 (2017-11-08)
The use of sustained-release mucoadhesive vaginal tablets of antiretroviral drugs as microbicidal formulations can be an effective strategy for reducing the sexual transmission of HIV from men to women, which is a main problem particularly in low- and middle-income countries.
Fernando Notario-Pérez et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 117, 204-215 (2018-02-27)
Sustained-release vaginal microbicides hold out great hope for the prevention of sexual transmission of HIV from men to women. Tenofovir (TFV) -an antiretroviral drug- sustained-release vaginal compacts combining two release control systems (by drug-loading granules with hydrophobic polymers and incorporating

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