223387
Nickel(II) chloride hexahydrate
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About This Item
Linear Formula:
NiCl2 · 6H2O
CAS Number:
Molecular Weight:
237.69
NACRES:
NA.55
PubChem Substance ID:
UNSPSC Code:
12352302
MDL number:
Form:
powder or crystals
General description
Nickel(II) chloride hexahydrate is a hydrated nickel salt. Its crystals were monoclinc and crystal structure was investigated by X-ray single crystal method.
Application
Nickel(II) chloride hexahydrate may be used as a catalyst in the following processes:
- Synthesis of tetra-substituted pyrrole derivatives via four-component condensation reaction of aromatic aldehydes, benzylamines, β-ketoesters and nitroalkanes.
- In combination with 1,2-ethanedithiol for the deprotection of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers to their corresponding hydroxyl compounds.
- Synthesis of 3,4-dihydropyrimidinones from aldehydes and β-keto esters via Biginelli condensation.
Nickel(II) chloride hexahydrate may be employed as a catalyst in the high yield synthesis of tetra-substituted pyrrole derivatives. It may be used for the conversion of tetrahydropyranyl (THP) and tert-butyldimethylsilyl (TBS) ethers to the corresponding hydroxyl compounds.
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Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
target_organs
Lungs
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Regulatory Information
危险化学品
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Articles
Nickel complexes catalyze various synthetic reactions like oxidative addition, C-H activation, and cross-coupling.
Catalysis of the Biginelli reaction by ferric and nickel chloride hexahydrates. One-pot synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones.
Lu J and Bai Y.
Synthesis, 2002(04), 0466-0470 (2002)
The Crystal Structure of Nickel Chloride Hexahydrate, NiCl2.6H2O.
Mizuno J.
Journal of the Physical Society of Japan, 16(8), 1571-1580 (1961)
Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel (II) chloride hexahydrate catalyzed one-pot four-component reaction.
Khan AT, et al.
Tetrahedron Letters, 53(32), 4145-4150 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 223387-25G | 04061838778369 |
| 223387-500G | 04061838778383 |
| 223387-2KG | 04061838778376 |