Skip to Content
Merck
CN

27635

Adipic acid

meets analytical specification of Ph.Eur., BP, E 355, 99.6-101.0% (calc. to the dried substance)

Synonym(s):

Hexanedioic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
HOOC(CH2)4COOH
CAS Number:
124-04-9
Molecular Weight:
146.14
UNSPSC Code:
12352106
PubChem Substance ID:
329753005
eCl@ss:
39021711
EC Number:
204-673-3
Beilstein/REAXYS Number:
1209788
MDL number:
MFCD00004420
Assay:
99.6-101.0% (calc. to the dried substance)
Form:
solid

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

WNLRTRBMVRJNCN-UHFFFAOYSA-N

InChI

1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)

vapor density

5 (vs air)

vapor pressure

1 mmHg ( 159.5 °C)

assay

99.6-101.0% (calc. to the dried substance)

form

solid

autoignition temp.

788 °F

quality

meets analytical specification of Ph.Eur., BP, E 355

impurities

residual solvents, complies, ≤0.001% heavy metals (as Pb), ≤0.2% water (Karl Fischer)

ign. residue

≤0.002% (as SO4)

loss

≤0.2% loss on drying, 105 °C

bp

265 °C/100 mmHg (lit.)

solubility

H2O: slightly soluble, H2O: soluble (Boiling), acetone: soluble, benzene: insoluble, cyclohexane: slightly soluble, ethanol: freely soluble, methanol: freely soluble, petroleum ether: insoluble

anion traces

chloride (Cl-): ≤50 mg/kg, nitrate (NO3-): ≤30 mg/kg, sulfate (SO42-): ≤500 mg/kg

cation traces

As: ≤3 mg/kg, Fe: ≤5 mg/kg, Hg: ≤1 mg/kg, Pb: ≤10 mg/kg, Pb: ≤5 mg/kg

suitability

passes test for appearance of solution

Looking for similar products? Visit Product Comparison Guide

Application

Adipic acid is an organic acid used for resolving the problem of pH-dependent release of weakly basic drugs.

Biochem/physiol Actions

Presence of adipic acid in the urine of ketotic patients is utilized as a marker for diagnosing the degree of ketosis.

Preparation Note

Adipic acid is freely soluble in ethanol and methanol. It also dissolves in boiling water, and acetone. Additionally, the product is slightly soluble in water and cyclohexane and is practically insoluble in benzene and petroleum ether.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

384.8 °F - closed cup

flash_point_c

196 °C - closed cup

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A Streubel et al.
Journal of controlled release : official journal of the Controlled Release Society, 67(1), 101-110 (2000-04-25)
Weakly basic drugs or salts thereof demonstrate pH-dependent solubility. The resulting release from conventional matrix tablets decreases with increasing pH-milieu of the gastrointestinal tract. The aim of this study was to overcome this problem and to achieve pH-independent drug release.
The occurrence of adipic and suberic acid in urine from ketotic patients.
J E Pettersen et al.
Clinica chimica acta; international journal of clinical chemistry, 38(1), 17-24 (1972-04-01)
Krzysztof J Paluch et al.
Journal of pharmaceutical sciences, 100(8), 3268-3283 (2011-04-08)
The production of salt or cocrystalline forms is a common approach to alter the physicochemical properties of pharmaceutical compounds. The goal of this work was to evaluate the impact of anion choice (succinate, adipate, and sulfate) on the physicochemical characteristics
J Greter et al.
The Journal of biological chemistry, 254(8), 2807-2813 (1979-04-25)
cis-3,4-Methylene hexanedioic acid has been discovered in human urine. It has been isolated and identified by mass spectrometry and synthesis. The daily excretion in nine subjects on a free diet was 88 mumol/day (range, 32 to 144 mumol/day). cis-3,4-Methylene hexanedioic
Roohan Rakhshaee et al.
Journal of hazardous materials, 189(1-2), 158-166 (2011-03-15)
The removal of methylene blue (MB) as a cationic dye from aqueous solution by the stabilized Fe(3)O(4) nano-particles with the extracted pectin from apple waste (FN-PA) increased due to using the cross-linked forms of the bound pectin on the nano-particles
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service