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Merck
CN

565423

Acetonitrile solution

suitable for HPLC, contains 0.035 % (v/v) trifluoroacetic acid

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
UNSPSC Code:
12190000
PubChem Substance ID:
329758110
EC Number:
200-835-2
Beilstein/REAXYS Number:
4124158
MDL number:
MFCD00001878
Grade:
HPLC grade
Technique(s):
HPLC: suitable
Bp:
81-82 °C
Vapor pressure:
72.8 mmHg

Key Documents

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Product Name

Acetonitrile solution, contains 0.035 % (v/v) trifluoroacetic acid, suitable for HPLC

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

InChI

1S/C2H3N/c1-2-3/h1H3

SMILES string

CC#N

grade

HPLC grade

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg

Quality Level

100

contains

0.035 % (v/v) trifluoroacetic acid

expl. lim.

8 %

technique(s)

HPLC: suitable

bp

81-82 °C

mp

-48 °C

density

0.782 g/mL at 25 °C

application(s)

food and beverages

format

mixture

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General description

The product is an acetonitrile solution containing 0.035%v/v trifluoroacetic acid. This pre-blended mobile phase solvent is of high purity that reduces time-consuming preparation and prevents instrument downtime because of impure mobile phases. Trifluoroacetic acid/acetonitrile mobile phase system is generally employed for peptide separation. Acetonitrile (MeCN), an organic solvent has low viscosity, high elution strength and is UV transparent at low wavelength. Trifluoroacetic acid (TFA) is commonly used as a mobile phase additive. It is a volatile acid that forms hydrophobic negatively charged trifluoroacetate ion.

Packaging

M-Bottle for Solvents
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pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

flash_point_f

42.8 °F - closed cup

flash_point_c

6 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SHBN9004
SHBD8326V
SHBD6337V
SHBD2645V
SHBD1527V

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Optimum concentration of trifluoroacetic acid for reversed-phase liquid chromatography of peptides revisited.
Chen Y, et al.
Journal of Chromatography A, 1043(1), 9-18 (2004)
Eagleson M.
Concise Encyclopedia Chemistry, 6-6 (1994)
Acetonitrile, the polarity chameleon.
Zarzycki PK, et al.
Analytical and Bioanalytical Chemistry, 397(3), 905-908 (2010)
Hélène Hall et al.
Brain : a journal of neurology, 137(Pt 9), 2493-2508 (2014-07-27)
The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic
Divya Subramonian et al.
Journal of proteome research, 13(9), 3905-3918 (2014-07-30)
SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is
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