Skip to Content
Merck
CN

E27408

1,2-Dimethoxyethane

ReagentPlus®, ≥99%, inhibitor-free

Synonym(s):

mono-Glyme, Dimethylglycol, Ethylene glycol dimethyl ether, Monoglyme

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Linear Formula:
CH3OCH2CH2OCH3
CAS Number:
110-71-4
Molecular Weight:
90.12
Beilstein:
1209237
EC Number:
203-794-9
MDL number:
MFCD00008502
UNSPSC Code:
12352112
PubChem Substance ID:
329799037
PubChem Substance ID:
57648156
NACRES:
NA.21
Assay:
≥99%
Bp:
85 °C (lit.)
Vapor pressure:
48 mmHg ( 20 °C)

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

vapor density

3.1 (20 °C, vs air)

Quality Level

100

vapor pressure

48 mmHg ( 20 °C)

product line

ReagentPlus®

Assay

≥99%

form

liquid

autoignition temp.

396 °F

expl. lim.

10.4 %

dilution

(for general lab use)

impurities

≤0.5% (water)

refractive index

n20/D 1.379 (lit.)

pH

7

bp

85 °C (lit.)

mp

−58 °C (lit.)

density

0.867 g/mL at 25 °C (lit.)

SMILES string

COCCOC

InChI

1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3

InChI key

XTHFKEDIFFGKHM-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

1,2-Dimethoxyethane (DME) is an inert aprotic polar solvent for electrolytes of lithium batteries, polysilicones, oligo- and polysaccharides.

Application

1,2-Dimethoxyethane can be used as a solvent to synthesize:
  • Oxazoles from α-acylamino ketones via Robinson-Gabriel reaction.
  • 5-Arylhistidines via Suzuki-Miyaura cross-coupling between 5-bromohistidine and arylboronic acids.
  • Aryl thioethers via Pd-catalyzed thioetherification of aryl halides with aliphatic and aromatic thiols.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H225,H315,H332,H360FD

Hazard Classifications

Acute Tox. 4 Inhalation - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

41.0 °F - closed cup

Flash Point(C)

5 °C - closed cup

Regulatory Information

危险化学品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SDBB6406
SHBT0952
SHBS8757
SHBR1819
STBK8943

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Organometallics, 13, 1498-1498 (1994)
Tetrahedron Letters, 34, 4591-4591 (1993)
Inorganic Chemistry, 33, 1685-1685 (1994)
Peter A Campochiaro et al.
Ophthalmology, 122(3), 545-554 (2014-12-03)
AKB-9778 is a small-molecule competitive inhibitor of vascular endothelial-protein tyrosine phosphatase (VE-PTP) that promotes Tie2 activation and reduces vascular leakage and neovascularization in mouse models. The purpose of this study was to test the safety, tolerability, pharmacokinetics, and biological activity
Andrew Martins et al.
Organic letters, 12(22), 5186-5188 (2010-10-19)
A palladium-catalyzed crossed biaryl coupling/reduction sequence enables the formation of meta-substituted biaryls via solvent-mediated arylpalladium(II) reduction. Isotope labeling studies determined that the decomposition of 1,2-dimethoxyethane (DME) is indeed involved in the reductive process.
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service