00010402
OX-23 hybridoma cell line
Anti- Factor H, human
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About This Item
UNSPSC Code:
41106514
NACRES:
NA.81
biological source
Mouse x Mouse Hybridoma
Quality Level
packaging
tube of 5 μg 00010402-DNA-5UG
pkg of vial of cells 00010402-1VL
ImmunoDon
BALB/c mouse spleen
Myeloma
NS0
Reactivity
Anti-Factor H, human
technique(s)
cell culture | mammalian: suitable
isotype
IgG1
Immunogen
Human Factor H
Biochem/physiol Actions
Mouse x Mouse hybridoma
The hybridoma line OX-23 was raised by immunizing BALB/c mice with Factor H and fusion of spleen cells with NS0 mouse myeloma cells. The antibody was shown to detect human complement control protein, Factor H. OX-23, also known as MRC OX-23, reduced the increase in cofactor activity observed in the presence of OX-24 (Sigma Catalogue no. 00010403). It was reported that OX-23 and OX-24 react with different epitopes on the Factor H molecule.
Packaging
NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.
Preparation Note
Maintain cultures between 3-9 x 100,000 cells/ml; 5% CO2; 37°C.
Other Notes
Additional freight & handling charges may be applicable for Asia-Pacific shipments. Please check with your local Customer Service representative for more information.
Disclaimer
This cell line has special release conditions: Commercial organisations are required to complete the ′Cell Line Release Authorisation for Research Use in Commercial Organisations′ release conditions form.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Daniel Ajona et al.
Cancer research, 64(17), 6310-6318 (2004-09-03)
The complement system is important in immunosurveillance against tumors. However, malignant cells are usually resistant to complement-mediated lysis. In this study, we examine the expression of factor H, an inhibitor of complement activation, and factor H-like protein 1 (FHL-1), its
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