00189
Sulfadimidine solution
1 mg/mL in H2O
Synonym(s):
Sulfamethazine solution
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About This Item
Empirical Formula (Hill Notation):
C12H14N4O2S
CAS Number:
Molecular Weight:
278.33
PubChem Substance ID:
UNSPSC Code:
51283901
Beilstein/REAXYS Number:
261304
MDL number:
SMILES string
Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
InChI
1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI key
ASWVTGNCAZCNNR-UHFFFAOYSA-N
form
liquid
concentration
1 mg/mL in H2O
color
colorless
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
enzyme | inhibits
Quality Level
Application
Sulfadimidine is used to induce cytochrome P450 3A4 (CYP3A4) and to inhibit dihydrofolate reductase (DHFR). It was used to study amantadine acetylation.
Biochem/physiol Actions
Sulfadimidine is a competitive inhibitor of dihydropteroate synthetase to block the synthesis of folic acid. It acts as an inhibitor of dihydrofolate reductase (DHFR).
Packaging
10ML
Other Notes
Conditions for safe storage,including any incompatibilities Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Light sensitive.
Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
Regulatory Information
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Gang Luo et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(7), 795-804 (2002-06-18)
Induction of cytochrome P450 3A4 (CYP3A4) is determined typically by employing primary culture of human hepatocytes and measuring CYP3A4 mRNA, protein and microsomal activity. Recently a pregnane X receptor (PXR) reporter gene assay was established to screen CYP3A4 inducers. To
A P Bras et al.
Drug metabolism and disposition: the biological fate of chemicals, 29(5), 676-680 (2001-04-17)
Amantadine acetylation was demonstrated to occur both in vivo and in vitro using transgenic male mice overexpressing spermidine/spermine N(1)-acetyltransferase (SSAT). We previously reported that neither NAT1 nor NAT2 was responsible for catalyzing acetylation of the primary amine group of amantadine.
Juan Gao et al.
Environmental science & technology, 46(5), 2642-2651 (2012-01-17)
The transformation of the sulfonamide antimicrobial sulfamethazine (SMZ) by a synthetic analogue of the birnessite-family mineral vernadite (δ-MnO(2)) was studied. The observed pseudo-first-order reaction constants (k(obs)) decreased as the pH increased from 4.0 to 5.6, consistent with the decline in
Marc Teixidó et al.
Environmental science & technology, 45(23), 10020-10027 (2011-10-27)
Adsorption of ionizable compounds by black carbon is poorly characterized. Adsorption of the veterinary antibiotic sulfamethazine (SMT; a.k.a., sulfadimidine; pK(a1) = 2.28, pK(a2) = 7.42) on a charcoal was determined as a function of concentration, pH, inorganic ions, and organic
Marina Islas-Espinoza et al.
Microbial ecology, 64(1), 140-151 (2012-01-31)
Persistence or degradation of synthetic antibiotics in soil is crucial in assessing their environmental risks. Microbial catabolic activity in a sandy loamy soil with pig manure using 12C- and 14C-labelled sulfamethazine (SMZ) respirometry showed that SMZ was not readily degradable.
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