02187
Isoorientin
≥98.0% (HPLC)
Synonym(s):
Homoorientin, Luteolin 6-C-β-D-glucoside, Luteolin 6-C-glucoside
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About This Item
Empirical Formula (Hill Notation):
C21H20O11
CAS Number:
Molecular Weight:
448.38
UNSPSC Code:
12352201
PubChem Substance ID:
MDL number:
assay
≥98.0% (HPLC)
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc3OC(=CC(=O)c3c2O)c4ccc(O)c(O)c4
InChI
1S/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2/t14-,17-,19+,20-,21+/m1/s1
InChI key
ODBRNZZJSYPIDI-VJXVFPJBSA-N
Biochem/physiol Actions
Luteolin, a common flavonoid, has been shown to inhibit secretion of ET-1 by porcine aortic endothelial cells at a 10 uM concentration. However, the luteolin glycoside compound, luteolin 6-C-glucoside, showed very weak inhibition of ET-1 release and inhibition only occurred at higher concentrations of luteolin 6-C-glucoside.
C-glycosyl flavone with anti-inflammatory, antimicrobial and antioxidant properties. Induces antioxidant response through PI3K singaling.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Luteolin inhibits endothelin-1 secretion in cultured endothelial cells.
Kozakai, T.
Biosciences, Biotechnology Research Asia, 69, 1613-1615 (2005)
Jinyong Peng et al.
Journal of chromatography. A, 1074(1-2), 111-115 (2005-06-09)
High-speed counter-current chromatography (HSCCC) with a solvent system composed of ethyl acetate-n-butanol-water (2:1:3, v/v/v) was used to isolate and separate two C-glycosylflavones from Patrinia villosa Juss, a traditional Chinese medicine. The separation produced 42.9 mg isovitexin and 20.1 mg isoorientin
Severina Pacifico et al.
Journal of natural products, 73(12), 1973-1978 (2010-11-18)
Eight flavonoid C-glycosides, including three new analogues, have been isolated from leaf and root methanolic extracts of Petrorhagia velutina, a Mediterranean herbaceous plant. The antiproliferative activity against human hepatoblastoma cancer cell line HepG2 has been analyzed by the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 250910-100G | 04061825937489 |
| 8019170250 | 04022536370965 |
| 250910-500G | 04061837633027 |