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Merck
CN

06880

4-Aminobenzamidine dihydrochloride

BioReagent, suitable for fluorescence, ≥99.0% (TLC)

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About This Item

Linear Formula:
H2NC6H4C(=NH)NH2·2HCl
CAS Number:
Molecular Weight:
208.09
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
219-692-2
MDL number:
Beilstein/REAXYS Number:
3692927
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product line

BioReagent

assay

≥99.0% (TLC)

form

powder or crystals

mp

>300 °C (lit.)

fluorescence

λex >300 nm in H2O

suitability

suitable for fluorescence

storage temp.

2-8°C

InChI

1S/C7H9N3.2ClH/c8-6-3-1-5(2-4-6)7(9)10;;/h1-4H,8H2,(H3,9,10);2*1H

InChI key

GHEHNICLPWTXJC-UHFFFAOYSA-N

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Analysis Note

Emmax: none

Other Notes

Competitive inhibitor of serine proteases; As a fluorescent probe for the active site of serine proteases

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamidine.
F Markwardt et al.
European journal of biochemistry, 6(4), 502-506 (1968-12-05)
STUDIES ON THE ACTIVE CENTER OF TRYPSIN. THE BINDING OF AMIDINES AND GUANIDINES AS MODELS OF THE SUBSTRATE SIDE CHAIN.
M MARES-GUIA et al.
The Journal of biological chemistry, 240, 1579-1585 (1965-04-01)
S A Evans et al.
The Journal of biological chemistry, 257(6), 3014-3017 (1982-03-25)
p-Aminobenzamidine is weakly fluorescent in neutral aqueous buffer, with excitation and emission maxima at 293 and 376 nm, respectively. Binding to trypsin results in a blue shift of the emission peak to 362 nm, and 50-fold fluorescence enhancement, while binding
Nathan J Alves et al.
Biochemical and biophysical research communications, 457(3), 358-362 (2015-01-13)
The potent fibrinolytic enzyme, plasmin has numerous clinical applications for recannulizing vessels obstructed by thrombus. Despite its diminutive size, 91 kDa, success in the recombinant expression of this serine protease has been limited. For this reason, a truncated non-glycosylated plasmin

Global Trade Item Number

SKUGTIN
14673-100MG04061838737083
220329-10G04061838776327
06880-5G04061833345818
06880-1G04061826651636

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