0710000
4-tert-Butylphenoxyacetic acid
≥98.0% (HPLC)
Synonym(s):
TAC acid, [4-(1,1-Dimethylethyl)phenoxy]-acetic acid
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About This Item
Linear Formula:
(CH3)3CC6H4OCH2CO2H
CAS Number:
Molecular Weight:
208.25
UNSPSC Code:
12352106
NACRES:
NA.26
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2368208
InChI
1S/C12H16O3/c1-12(2,3)9-4-6-10(7-5-9)15-8-11(13)14/h4-7H,8H2,1-3H3,(H,13,14)
SMILES string
CC(C)(C)c1ccc(OCC(O)=O)cc1
InChI key
FBIGAJNVRFKBJL-UHFFFAOYSA-N
assay
≥98.0% (HPLC)
mp
96 °C (lit.)
Application
Reagent for the TAC protective group in nucleosides
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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N D Sinha et al.
Biochimie, 75(1-2), 13-23 (1993-01-01)
The use of tert-butylphenoxyacetyl for N-protection of nucleoside bases during oligonucleotide synthesis facilitates its removal under mild conditions. This protecting group reduces depurination of deoxyadenosine residues, and minimizes premature desilylation resulting in chain degradation during post-synthesis workup of synthetic RNA.
Katarzyna Przejczowska-Pomierny et al.
Chirality, 29(9), 500-511 (2017-07-06)
A direct fluorometric high-performance liquid chromatography (HPLC) method was developed and validated for the analysis of ibuprofen enantiomers in mouse plasma (100 μl) and tissues (brain, liver, kidneys) using liquid-liquid extraction and 4-tertbutylphenoxyacetic acid as an internal standard. Separation of enantiomers
K E Cole et al.
The Journal of experimental medicine, 187(12), 2009-2021 (1998-06-24)
Chemokines are essential mediators of normal leukocyte trafficking as well as of leukocyte recruitment during inflammation. We describe here a novel non-ELR CXC chemokine identified through sequence analysis of cDNAs derived from cytokine-activated primary human astrocytes. This novel chemokine, referred
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