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Merck
CN

07298

FabRICATOR®

for cleaving 2 mg IgG, 2000 U/vial

Synonym(s):

IdeS from Streptococcus pyogenes

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About This Item

UNSPSC Code:
12352204
EC Number:
3.4.22
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form

powder

specific activity

2000 U/vial

storage temp.

−20°C

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Analysis Note

SDS gel electrophoresis ≥ 95 % purity

Other Notes

One unit is defined as the amount of enzyme required to fragment 95% of 1 ug of human IgG in 30 minutes at 37°C, pH 6.6 as monitored by SDS-PAGE.

Legal Information

FabRICATOR is a registered trademark of Genovis AB

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Mary H Ryan et al.
Molecular immunology, 45(7), 1837-1846 (2007-12-26)
A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A
Johnson Agniswamy et al.
The Journal of biological chemistry, 279(50), 52789-52796 (2004-10-07)
Group A Streptococcus has evolved numerous mechanisms to evade the host immune system to survive, disseminate, and cause disease. Recently a secreted protein named Mac-1 was identified and shown to enhance survival of the pathogen. A new variant of Mac-1
Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin.
Leontyev, D., et al.
Transfusion, doi: 10-doi: 10 (2012)
Antonina Pechkovsky et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(19), E1724-E1733 (2013-04-25)
The adenovirus E4orf4 protein regulates the progression of viral infection, and when expressed alone in mammalian tissue culture cells it induces protein phosphatase 2A (PP2A)-B55- and Src-dependent cell death, which is more efficient in oncogene-transformed cells than in normal cells.
M Lišková et al.
Analytical and bioanalytical chemistry, 400(2), 369-379 (2011-02-08)
A number of biologically important molecules, such as DNA, proteins, and antibodies, are routinely conjugated with fluorescent tags for high-sensitivity analyses. Here, the application of quantum dots in the place of bright and size-tunable luminophores is studied. Several selected bioconjugation

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