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Merck
CN

11040

L-Arginine monohydrochloride

≥99.0% (AT)

Synonym(s):

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
1119-34-2
Molecular Weight:
210.66
EC Number:
214-275-1
UNSPSC Code:
12352209
MDL number:
MFCD00064550
Beilstein/REAXYS Number:
3631658

Key Documents

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assay

≥99.0% (AT)

optical activity

[α]20/D +22.0±0.5°, c = 5% in 5 M HCl

impurities

≤0.3% foreign amino acids

ign. residue

≤0.1% (as SO4)

loss

≤0.1% loss on drying

solubility

H2O: freely soluble, alcohol: slightly soluble (Hot)

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

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Application

L-Arginine hydrochloride has been used as a test compound for examining the impact of L-NG-monomethyl arginine (L-NMMA) and L-NG-nitro arginine (L-NOARG) on non-adrenergic, non-cholinergic relaxations of mouse anococcygeus muscle. It has also been used as a standard test compound for investigating whether the absolute concentration of a protein within a mixture of other proteins can be measured with SI traceability.

Biochem/physiol Actions

L-Arginine enhances the urine urea excretion and has increased values for glomerular filtration rate (GFR) and P-amino hippurate (PAH) clearance in rats with remnant kidneys.
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP2328
BCCP2327
BCCN7401
BCCM8076
BCCM7583

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A Gibson et al.
British journal of pharmacology, 99(3), 602-606 (1990-03-01)
1. The effects of L-NG-monomethyl arginine (L-NMMA) and L-NG-nitro arginine (L-NOARG) on non-adrenergic, non-cholinergic (NANC) relaxations of the mouse anococcygeus were investigated. 2. L-NMMA (10-200 microM) produced a concentration-related inhibition of the NANC response; the inhibitory effect of 50 microM
A A Reyes et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 20(2), 168-176 (1992-08-01)
We studied the effect of dietary supplementation with L-arginine for 6 weeks on the progression of renal disease in female Sprague-Dawley rats subjected to sham-operation (groups 1 and 2) or surgical ablation of 85% to 90% of the total renal
William I Burkitt et al.
Analytical biochemistry, 376(2), 242-251 (2008-03-14)
Here we present a demonstration of the proof of principle that absolute concentration of a protein within a mixture of other proteins can be measured with SI traceability. The method used was based on tryptic digestion of a protein followed
Nivaldo Ribeiro Villela et al.
Journal of translational medicine, 12, 232-232 (2014-08-26)
Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. This paper investigates the role of the nitric oxide
Jenna Gallie et al.
PLoS biology, 13(3), e1002109-e1002109 (2015-03-13)
Phenotype switching is commonly observed in nature. This prevalence has allowed the elucidation of a number of underlying molecular mechanisms. However, little is known about how phenotypic switches arise and function in their early evolutionary stages. The first opportunity to
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