14825
Bis(4-fluoro-3-nitrophenyl) sulfone
≥97.0% (HPLC)
Synonym(s):
4,4′-Difluoro-3,3′-dinitrodiphenyl sulfone, 4-Fluoro-3-nitrophenyl sulfone
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About This Item
Linear Formula:
[FC6H3(NO2)]2SO2
CAS Number:
Molecular Weight:
344.25
EC Number:
206-224-7
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2486439
MDL number:
assay
≥97.0% (HPLC)
mp
191-194 °C
SMILES string
[O-][N+](=O)c1cc(ccc1F)S(=O)(=O)c2ccc(F)c(c2)[N+]([O-])=O
InChI
1S/C12H6F2N2O6S/c13-9-3-1-7(5-11(9)15(17)18)23(21,22)8-2-4-10(14)12(6-8)16(19)20/h1-6H
InChI key
KHAWDEWNXJIVCJ-UHFFFAOYSA-N
Application
Bis(4-fluoro-3-nitrophenyl) sulfone has been used to study the high-affinity ATP-binding site on 30S dynein, as well as the staphylococcal protein A in immunoferritin techniques. Bis(4-fluoro-3-nitrophenyl) sulfone has also been used to study ATPase activity and pellet height response of tetrahymena cilia.
Other Notes
Bifunctional reagent for investigating the folding of polypeptide chains; Crosslinking reagent via amino and phenolic hydroxy groups
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Cross-linking of aminotyrosyl residues in the active site of staphylococcal nuclease.
P Cuatrecasas et al.
The Journal of biological chemistry, 244(2), 406-412 (1969-01-25)
F. Wold
Methods in Enzymology, 11, 617-617 (1967)
J J Blum et al.
Journal of supramolecular structure, 11(2), 117-122 (1979-01-01)
The enhancing effect of low concentrations (eg, 8 microM) of bis(4-fluoro-3-nitrophenyl)sulfone (FNS) on 30S dynein ATPase activity is increased when 1 mM dithiothreitol (DTT) is present. The effect of FNS + DTT is optimal at pH 7.5. Activation of the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 632929-1G | 04061832721460 |
| 632929-5G | 04061832721477 |