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Merck
CN

17884

Sigma-Aldrich

3-(2-Furoyl)quinoline-2-carboxaldehyde

≥95% (HPLC), suitable for fluorescence, BioReagent

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About This Item

Empirical Formula (Hill Notation):
C15H9NO3
CAS Number:
126769-01-5
Molecular Weight:
251.24
MDL number:
MFCD03427748
UNSPSC Code:
12171500
PubChem Substance ID:
57647686
NACRES:
NA.32

Key Documents

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product line

BioReagent

Assay

≥95% (HPLC)

form

powder

solubility

methanol: soluble

fluorescence

λex 486 nm; λem ~600 nm in 0.1 M sodium borate pH 9.0 (after derivatization with glycine)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

[H]C(=O)c1nc2ccccc2cc1C(=O)c3ccco3

InChI

1S/C15H9NO3/c17-9-13-11(15(18)14-6-3-7-19-14)8-10-4-1-2-5-12(10)16-13/h1-9H

InChI key

PNCHURHVMDRFTR-UHFFFAOYSA-N

General description

3-(2-Furoyl)quinoline-2-carboxaldehyde is a neutral fluorogenic probe for amines for the picomolar assay of proteins by capillary electrophoresis (CE).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7828
BCCM6948
BCCL3469
BCCJ8073
BCCJ4778

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Haley R Pugsley et al.
Journal of chromatography. A, 1216(15), 3418-3420 (2009-03-03)
A number of algorithms have been developed to correct for migration time drift in capillary electrophoresis. Those algorithms require identification of common components in each run. However, not all components may be present or resolved in separations of complex samples
Roza Wojcik et al.
Journal of chromatography. A, 1194(2), 243-248 (2008-05-16)
3-(2-Furoyl)quinoline-2-carboxaldehyde (FQ), Chromeo P465, and Chromeo P503 are weakly fluorescent reagents that react with primary amines to produce fluorescent products. We studied the reaction of these reagents with alpha-lactalbumin by mass spectrometry. The reaction generated a set of products by
D P Richards et al.
Journal of chromatography. A, 853(1-2), 21-25 (1999-09-16)
We studied the effects of fluorescent labeling on the isoelectric points (pI values) of proteins using capillary isoelectric focusing with laser-induced fluorescence detection (cIEF-LIF). Specifically, we labeled green fluorescent protein (GFP) from the jellyfish Aequorea victoria with the fluorogenic dye
Raul Garrido-Medina et al.
Methods in molecular biology (Clifton, N.J.), 984, 207-225 (2013-02-07)
Sample preparation and laser-induced fluorescence detection are two key steps of the analytical methodology to determine by capillary electrophoresis low concentrations of proteins in complex sample matrices. In this chapter the options of performing both steps in different ways are
S C Beale et al.
Journal of chromatography, 499, 579-587 (1990-01-19)
3-(2-Furoyl)quinoline-2-carbaldehyde (FQCA) has been synthesized and characterized as a fluorogenic derivatizing reagent for liquid chromatography. The reagent forms highly fluorescent isoindoles upon reaction with primary amines. The spectral properties and optimum reaction conditions for the formation of isoindoles have been
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