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Merck
CN

30030

Cymarin

≥96% (HPLC)

Synonym(s):

K-Strophanthidin-D-cymaroside, K-Strophanthin-α

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About This Item

Empirical Formula (Hill Notation):
C30H44O9
CAS Number:
508-77-0
Molecular Weight:
548.66
UNSPSC Code:
12352211
NACRES:
NA.77
PubChem Substance ID:
57648403
EC Number:
208-087-9
Beilstein/REAXYS Number:
101370
MDL number:
MFCD00003669

Key Documents

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Product Name

Cymarin, ≥96% (HPLC)

InChI key

XQCGNURMLWFQJR-ZNDDOCHDSA-N

InChI

1S/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22-,23+,25+,26-,27-,28+,29+,30+/m1/s1

SMILES string

CO[C@H]1C[C@@H](O[C@H](C)[C@H]1O)O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6

assay

≥96% (HPLC)

Quality Level

100

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Application

Cymarin was used to study the effect of cardiac glycosides on vascular smooth muscles and ion transport.

Biochem/physiol Actions

Cymarin is a cardiac glycoside and is classified as cardiotonic steroid. It inhibits ion transport by decreasing the activity of (Na-K)-ATPase.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK7224
BCCC9196
BCCB2296
BCBX6134
BCBW0159

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Z B Skorzova et al.
Sudebno-meditsinskaia ekspertiza, 32(2), 35-36 (1989-04-01)
Private technique of extraction isolation and purification, chromatographic detection and photometric determination of zimarin in urine is suggested. Detection limit is 0.01 mg, determination limit is 0.1 mg of glycoside in 100 ml of urine. Method makes it possible to
E V Lopatina et al.
Bulletin of experimental biology and medicine, 146(6), 744-746 (2009-06-11)
We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M)
Iu I Pivovarov et al.
Biulleten' eksperimental'noi biologii i meditsiny, 96(8), 24-28 (1983-08-01)
Experiments on rats were made to study the character of rhythmical activity of intact heart and heart with abnormal reactivity under electrical stimulation of the blue spot (BS) and formation in it of the generator of pathologically enhanced excitation (GPEE)
Increased in vivo synthesis of retinal Na pump isoforms after pre-treatment with citrate buffer.
S C Specht et al.
Progress in clinical and biological research, 268B, 143-147 (1988-01-01)
C Giunta et al.
General pharmacology, 16(3), 183-188 (1985-01-01)
Ouabain and K-strophanthoside promote an enhancement of Na+/K+-ATPase activity in a range of cardioglycoside concentrations from 100 nM to 100 pM, with a maximum (+30%) between 10 and 4 nM. Binding experiments with [3H]ouabain show upward-curved Scatchard plots and evidence
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