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30927

2′-Deoxyadenosine 5′-triphosphate disodium salt

≥90% (HPLC)

Synonym(s):

dATP-Na2

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About This Item

Empirical Formula (Hill Notation):
C10H14N5Na2O12P3
CAS Number:
74299-50-6
Molecular Weight:
535.15
UNSPSC Code:
41106305
PubChem Substance ID:
329753606
EC Number:
277-809-2
MDL number:
MFCD00080335
eCl@ss:
32160414
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assay

≥90% (HPLC)

storage temp.

−20°C

SMILES string

[Na+].[Na+].Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O3

InChI

1S/C10H16N5O12P3.2Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;/q;2*+1/p-2/t5-,6+,7?;;/m0../s1

InChI key

JEKDCIBJADJZSK-LNUHRGGJSA-L

Application

2′-Deoxyadenosine 5′-triphosphate (dATP) is used as a substrate by a variety of polymerases including DNA polymerase(s) and reverse transcriptase(s).

Other Notes

Substrate for DNA polymers for studying the mechanism of DNA replication

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Jennifer N Patro et al.
Biochemistry, 48(1), 180-189 (2008-12-17)
We used a series of dNTP analogues in conjunction with templates containing modified bases to elucidate the role that N(2) of a purine plays during dNTP polymerization by human DNA polymerase alpha. Removing N(2) from dGTP had small effects during
Fadia Haddad et al.
Methods in molecular biology (Clifton, N.J.), 630, 261-270 (2010-03-20)
Reverse transcription (RT) is the synthesis of complementary deoxyribonucleic acids (DNA) from single-stranded ribonucleic acid (RNA) templates. This process is catalyzed by the reverse transcriptase enzyme, which is the replicating enzyme of retroviruses. Reverse transcriptase was discovered in 1970, and
Michael Trostler et al.
Biochemistry, 48(21), 4633-4641 (2009-04-08)
We used a series of dATP and dGTP analogues to determine how DNA polymerase I from Bacillus stearothermophilus (BF), a prototypical A family polymerase, uses N-1, N(2), N-3, and N(6) of purine dNTPs to differentiate between right and wrong nucleotide
W M Kati et al.
The Journal of biological chemistry, 267(36), 25988-25997 (1992-12-25)
We have examined the RNA-dependent and DNA-dependent polymerase and ribonuclease H catalytic activities of human immunodeficiency virus reverse transcriptase using rapid transient kinetic methods with defined synthetic 25/45-mer DNA/RNA and DNA/DNA primer/templates. The Kd value for interaction of the enzyme
J E Reardon
Biochemistry, 31(18), 4473-4479 (1992-05-12)
Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templates. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was almost as efficient a substrate (kcat/Km) as dTTP for the enzyme. In contrast, the
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