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Merck
CN

317M-1

Sigma-Aldrich

Cytokeratin 17 (Ks 17.E3) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

Ks 17.E3, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (317M-14)
vial of 0.5 mL concentrate (317M-15)
bottle of 1.0 mL predilute (317M-17)
vial of 1.0 mL concentrate (317M-16)
bottle of 7.0 mL predilute (317M-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG2b

control

cervix neoplasia III

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT17(3872)

General description

Cytokeratin 17 is 46 kD intermediate filament found in simple epithelia sometimes in association with Cytokeratin 7. This antibody has been used to distinguish cervical immature squamous metaplasia from high grade cervical intraepithelial neoplasia (CIN III). Anti-CK 17 also labels myoepithelial cells in the benign breast tissue. CK 17 labelling of breast carcinoma cells (so-called basal phenotype) has been associated with a poor prognosis.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD
IVD
IVD
RUO

Other Notes

Cytokeratin 17 Positive Control Slides , Product No. 317S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000116156
0000086213
0000086214
0000052478
0000039509

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Peiguo G Chu et al.
The American journal of surgical pathology, 29(3), 359-367 (2005-02-24)
Pancreatobiliary and ampulla of Vater adenocarcinomas frequently metastasize to regional lymph nodes, liver, or lung and are difficult to diagnose because they lack specific immunohistochemical markers. We studied the expression of cytokeratin 7 (CK7), cytokeratin 17 (CK17), cytokeratin 20 (CK20)
Jolise E Martens et al.
Anticancer research, 24(2B), 771-775 (2004-05-27)
Basic research on HPV has focused on identifying the genetic changes that lead to cervical carcinoma. However, while focusing on the molecular biology of the cancer, understanding of its cellular biology has lagged: the target cell of the HPV infection
S Regauer et al.
Histopathology, 50(5), 629-635 (2007-03-31)
Atypical immature metaplasia (AIM) refers to a full-thickness intraepithelial basaloid lesion in the uterine cervix that features both metaplasia and atypia and is therefore difficult to distinguish from high-grade cervical intraepithelial neoplasia (CIN III). p16 is a marker for human
Raanan Cohen-Kerem et al.
The Annals of otology, rhinology, and laryngology, 113(10), 821-827 (2004-11-13)
To assess cytokeratin-17 (CK17) as an immunohistochemical marker for squamous cell carcinoma of the larynx, we stained 63 tissue samples from 63 consecutive patients who were believed or suspected to have squamous cell carcinoma of the larynx for CK17 and

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