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347R-2

Sigma-Aldrich

Vimentin (EP21) Rabbit Monoclonal Primary Antibody

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biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP21, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (347R-24)
vial of 0.1 mL concentrate Research Use Only (347R-24-RUO)
vial of 0.5 mL concentrate (347R-25)
vial of 1.0 mL concentrate (347R-26)
vial of 1.0 mL concentrate Research Use Only (347R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (347R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (347R-27)
vial of 7.0 mL pre-dilute ready-to-use (347R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (347R-28-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

isotype

IgG

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... VIM(7431)

Related Categories

General description

Anti-vimentin recognizes a 57-kDa intermediate filament initially isolated from mouse fibroblast culture. Anti-vimentin often serves as a useful control marker to ensure that the tissue has been properly preserved and processed. Expression of vimentin, when used in conjunction with keratin, is helpful when distinguishing melanomas from undifferentiated carcinomas and large cell lymphomas. All melanomas and schwannomas react strongly with vimentin. It labels a variety of mesenchymal cells, including melanocytes, lymphocytes, endothelial cells, and fibroblasts. In the area of gynecologic tumors, uterine endometrioid adenocarcinomas display a highly characteristic immunophenotype, with coexpression of low molecular wt. cytokeratin and vimentin.

Quality


IVD
IVD
IVD
RUO

Linkage

Vimentin Positive Control Slides, Product No. 347S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Diagnostic Immunohistochemistry (Masson Publishing) (2010)
D J Dabbs et al.
The American journal of surgical pathology, 10(8), 568-576 (1986-08-01)
We examined the distribution of high- and low-molecular-weight cytokeratins, vimentin, and carcinoembryonic antigen (CEA) in normal endometrial glands and endocervical glands (20 cases each) and in endometrial and endocervical adenocarcinomas (29 cases and 15 cases respectively). Low- and high-molecular-weight cytokeratin
D J Dabbs et al.
Human pathology, 27(2), 172-177 (1996-02-01)
Carcinomas of endometrioid histology frequently arise in the endometrium, ovary, and endocervix and involve the pelvic tissues in women. Adenocarcinomas of psuedoendometrioid morphology developing in the colon also frequently involve the ovary. The authors retrospectively examined 97 adenocarcinomas from the
H Yaziji et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 20(1), 64-78 (2001-02-24)
Ancillary techniques such as immunohistochemistry (IHC) enable the surgical pathologist to extract additional information from fixed, deparaffinized tissue specimens and to provide data critical to optimal clinical management of the patient. In this review of applications of IHC to the

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