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Merck
CN

41101

Sigma-Aldrich

Micro particles based on polymethacrylate

size: 100 μm

Synonym(s):

2-Propenoic acid,2-methyl homopolymer, 2-methyl-2-propenoic acid homopolymer, Microparticles based on PMAA, Microparticles based on poly(methacrylic acid), Polymethacrylate

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About This Item

MDL number:
MFCD00198073
UNSPSC Code:
12352202
NACRES:
NA.32

Key Documents

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form

suspension

concentration

10% (solids)

particle size

100 μm std dev 3 μm

storage temp.

2-8°C

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Application

Micro particles based on polymethacrylate, 100 μm may be used in drug delivery development applications.

Analysis Note

The exact values for particle size and standard deviation are determined for each lot and may be found on the certificate of analysis. These values are determined with an accuracy of 0.01 μm (Coulter Multisizer). Polymethacrylate based particles have a narrow size distribution and spherical shape. They are stable at temperatures of up to 100 °C Density is 1.22 g/cm3. The surface is negatively charged. Good biocompatibility and reduced nonspecific protein binding are characteristic.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1284358
1148194
1148195
437175/1

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V Agarwal et al.
Die Pharmazie, 63(2), 122-128 (2008-04-03)
The objectives of the present study were (A) to characterize insulin microparticles prepared by the coprecipitation process by size exclusion chromatography, differential scanning calorimetry, fourier-transform IR spectroscopy, and powder X-ray diffractometry, and (B) to study the solid state conformation of
Hagar Ibrahim Labouta et al.
Pharmaceutical research, 27(10), 2106-2118 (2010-07-24)
Evaluating the potentials of particulate delivery systems in topical drug delivery. Polymethacrylate microparticles (MPs) incorporating verapamil hydrochloride (VRP) as a model hydrophilic drug with potential topical clinical uses, using Eudragit RS100 and Eudragit L100 were prepared for the formulation of
Daniel S Kohane et al.
Pharmaceutical research, 20(10), 1533-1538 (2003-11-19)
pH-triggered microparticles release their therapeutic payloads at acidic pH (e.g., in the phagosome), making intracellular drug delivery more efficient. Here we modify lipid-based microparticles that are safe and efficacious in nerve and brain and are potentially inhalable, making them pH-triggerable
S Sajeesh et al.
Drug delivery, 18(4), 227-235 (2010-11-12)
The study was aimed at the evaluation of N-vinyl pyrrolidone (NVP) incorporated polymethacrylic acid-chitosan microparticles for oral drug delivery applications. Poly (methacrylic acid)-chitosan (PMC) and poly(methacrylic acid-vinyl pyrrolidone)-chitosan (PMVC) microparticles were prepared by an ionic-gelation method. Mucoadhesion behaviour of these

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