43683
Disialoganglioside GD3 from bovine milk
≥90% (TLC), ammonium salt
Synonym(s):
Ganglioside GD3, disialo
biological source
microbial
assay
≥90% (TLC)
form
powder
lipid type
sphingolipids
storage temp.
−20°C
Biochem/physiol Actions
Disialoganglioside GD3 plays an important role in CD95- and ceramide-induced apoptosis in hematopoietic cells as well as TNF-α-induced apoptosis iin hepatocytes and colon cells , thus acting as a cell death effector.
Other Notes
Sales restrictions may apply
Tumor-specific antigen in malignant melanoma. Antibodies to GD3 can induce partial remission of tumor growth in animals and humans
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
ppe
Eyeshields, Gloves, type N95 (US)
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P Hersey et al.
Cancer immunology, immunotherapy : CII, 24(2), 144-150 (1987-01-01)
Previous studies have shown that monoclonal antibodies (M.Ab) to the ganglioside GD3 may induce partial remissions in tumour growth in patients with melanoma. In vitro studies demonstrated that M.Abs to GD3 may also enhance lymphocyte responses to phytohemagglutinin and interleukin
Carmen García-Ruiz et al.
The Journal of biological chemistry, 277(39), 36443-36448 (2002-07-16)
The interaction of mitochondria with proapoptotic proteins activates apoptosis pathways. Previous findings have identified ganglioside GD3 (GD3) as an emerging apoptotic lipid intermediate that targets mitochondria in response to death signals. Using immunoelectron and laser scanning confocal microscopy, we characterize
Anna Colell et al.
FEBS letters, 526(1-3), 135-141 (2002-09-05)
In the present study we assessed the contribution of acidic sphingomyelinase (ASMase), a ceramide generating enzyme, in tumor necrosis factor (TNF)-mediated apoptosis in human colon HT-29 cells. TNF induced apoptosis in HT-29 cells in a time- and dose-dependent fashion. Downregulation
R De Maria et al.
Science (New York, N.Y.), 277(5332), 1652-1655 (1997-09-12)
Gangliosides participate in development and tissue differentiation. Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation. CD95-induced GD3 accumulation depended on integral receptor "death domains"
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