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Merck
CN

44977

DISBAC2(3), Voltage Sensitive Probe

≥98% (HPLC)

Synonym(s):

5-[3-(1,3-Diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-ylidene]-1,3-diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione, Bis(1,3-diethylthiobarbituric acid)trimethine oxonol

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About This Item

Empirical Formula (Hill Notation):
C19H24N4O4S2
CAS Number:
47623-98-3
Molecular Weight:
436.55
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
329756577
EC Number:
256-325-5
Beilstein/REAXYS Number:
1232950
MDL number:
MFCD07437858

Key Documents

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Product Name

DISBAC2(3), Voltage Sensitive Probe, ≥98% (HPLC)

InChI key

VJYNRXFXHKIGLT-MDZDMXLPSA-N

InChI

1S/C19H24N4O4S2/c1-5-20-14(24)12(15(25)21(6-2)18(20)28)10-9-11-13-16(26)22(7-3)19(29)23(8-4)17(13)27/h9-12H,5-8H2,1-4H3/b10-9+

SMILES string

CCN1C(=O)C(\C=C\C=C2\C(=O)N(CC)C(=S)N(CC)C2=O)C(=O)N(CC)C1=S

assay

≥98% (HPLC)

fluorescence

λex 535 nm; λem 560 nm in DMSO

suitability

complies for Infrared spectrum

storage temp.

−20°C

Quality Level

100

Application

DISBAC2(3), Voltage Sensitive Probe is used for single-cell fluorescence imaging of transmembrane conductance and potential change.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH0621
BCCF8360
BCCD1917
BCBH2187V

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A G Cabado et al.
Journal of cellular physiology, 158(2), 309-316 (1994-02-01)
We studied, in different ionic conditions, the effect of various agents on the membrane potential of rat peritoneal mast cells using the fluorescent probe bisoxonol. Ouabain and ionophore A23187 lead to a fast depolarization of the plasma membrane of mast
A B Al-Mehdi et al.
American journal of respiratory cell and molecular biology, 18(5), 653-661 (1998-06-06)
We hypothesize that lung ischemic injury is related to cessation of flow leading to endothelial cell membrane depolarization and activation of oxidant-generating systems. Cell membrane potential was assessed in isolated, oxygen ventilated, Krebs-Ringer bicarbonate buffer-dextran-perfused rat lungs by lung surface
Konstantinos Papadimitriou et al.
International journal of food microbiology, 111(3), 197-205 (2006-08-29)
Flow cytometry in combination with fluorescence probes was applied to rapidly assess the physiological status of Streptococcus macedonicus ACA-DC 198, a newly described member of the lactic acid bacteria group with technologically important features (e.g. lantibiotic production). A sonication procedure
P He et al.
Microvascular research, 50(2), 183-198 (1995-09-01)
The membrane potential is an important modulator of calcium ion flux into endothelial cells of venular microvessels. We developed a method to measure the membrane potential of endothelial cells forming the walls of individually perfused microvessels under the same experimental
Chiara Callies et al.
Nanotechnology, 20(17), 175104-175104 (2009-05-08)
The degree of mechanical stiffness of vascular endothelial cells determines the endogenous production of the vasodilating gas nitric oxide (NO). However, the underlying mechanisms are not yet understood. Experiments on vascular endothelial cells suggest that the electrical plasma membrane potential
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