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Merck
CN

44977

Sigma-Aldrich

DISBAC2(3), Voltage Sensitive Probe

≥98% (HPLC)

Synonym(s):

5-[3-(1,3-Diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-ylidene]-1,3-diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione, Bis(1,3-diethylthiobarbituric acid)trimethine oxonol

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About This Item

Empirical Formula (Hill Notation):
C19H24N4O4S2
CAS Number:
47623-98-3
Molecular Weight:
436.55
Beilstein:
1232950
EC Number:
256-325-5
MDL number:
MFCD07437858
UNSPSC Code:
12352108
PubChem Substance ID:
329756577
NACRES:
NA.32

Key Documents

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Assay

≥98% (HPLC)

fluorescence

λex 535 nm; λem 560 nm in DMSO

suitability

complies for Infrared spectrum

storage temp.

−20°C

SMILES string

CCN1C(=O)C(\C=C\C=C2\C(=O)N(CC)C(=S)N(CC)C2=O)C(=O)N(CC)C1=S

InChI

1S/C19H24N4O4S2/c1-5-20-14(24)12(15(25)21(6-2)18(20)28)10-9-11-13-16(26)22(7-3)19(29)23(8-4)17(13)27/h9-12H,5-8H2,1-4H3/b10-9+

InChI key

VJYNRXFXHKIGLT-MDZDMXLPSA-N

Application

DISBAC2(3), Voltage Sensitive Probe is used for single-cell fluorescence imaging of transmembrane conductance and potential change.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH0621
BCCF8360
BCCD1917
BCBH2187V

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Yi Tang et al.
Assay and drug development technologies, 4(4), 461-471 (2006-09-02)
Adenosine-3',5'-cyclic monophosphate (cAMP) conveys the signals from G-protein coupled receptors (GPCRs) and regulates a variety of downstream cellular events. However, there are few robust assays available for measuring cAMP in live cells. Most of the existing cAMP assays require cell
M Renier et al.
Human gene therapy, 6(10), 1275-1283 (1995-10-01)
Cystic fibrosis is caused by defects in a chloride-transporting protein termed cystic fibrosis transmembrane conductance regulator (CFTR). This study presents an innovative procedure to evaluate expression of functional CFTR. The technique uses the potential-sensitive probe bis-(1,3-diethylthiobarbituric acid) trimethine oxonol or
Chiara Callies et al.
Nanotechnology, 20(17), 175104-175104 (2009-05-08)
The degree of mechanical stiffness of vascular endothelial cells determines the endogenous production of the vasodilating gas nitric oxide (NO). However, the underlying mechanisms are not yet understood. Experiments on vascular endothelial cells suggest that the electrical plasma membrane potential
L H Brent et al.
Journal of cellular physiology, 168(1), 155-165 (1996-07-01)
Myeloid cells, including granulocytes and monocyte/macrophages, are important in disease-associated inflammatory reactions. These cells come from a common progenitor, the promyelocyte. The human promyelocytic cell line, HL-60, can be induced to terminally differentiate into granulocytes or monocyte/ macrophages in a
A G Cabado et al.
Journal of cellular physiology, 158(2), 309-316 (1994-02-01)
We studied, in different ionic conditions, the effect of various agents on the membrane potential of rat peritoneal mast cells using the fluorescent probe bisoxonol. Ouabain and ionophore A23187 lead to a fast depolarization of the plasma membrane of mast
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