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50214

Dy-677 NHS ester

Name: Dy-677 NHS ester
Brand: SIGMA

suitable for fluorescence

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About This Item

Empirical Formula (Hill Notation):

C₄₇H₄₉N₃Na₂O₁₄S₃

Molecular Weight:

1022.08

NACRES:

NA.32

PubChem Substance ID:

329757579

UNSPSC Code:

12352200

MDL number:

MFCD12912384

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Properties

form

solid

fluorescence

λ_ex 666 nm; λ_em 700 nm in 0.1 M phosphate pH 7.0

suitability

corresponds for coupling to amines, suitable for fluorescence

storage temp.

2-8°C

SMILES string

[Na+].[Na+].CC1=CC(C)(C)N(CCCS([O-])(=O)=O)c2cc3[o+]c(cc(\C=C\C=C4/N(CCCS([O-])(=O)=O)c5ccc(cc5C4(C)CCCC(=O)ON6C(=O)CCC6=O)S([O-])(=O)=O)c3cc12)-c7ccccc7

InChI

1S/C47H51N3O14S3.2Na/c1-31-30-46(2,3)49(23-11-25-66(57,58)59)39-29-41-36(28-35(31)39)33(26-40(63-41)32-12-6-5-7-13-32)14-8-15-42-47(4,21-9-16-45(53)64-50-43(51)19-20-44(50)52)37-27-34(67(60,61)62)17-18-38(37)48(42)22-10-24-65(54,55)56;;/h5-8,12-15,17-18,26-30H,9-11,16,19-25H2,1-4H3,(H2-,54,55,56,57,58,59,60,61,62);;/q;2*+1/p-2/b14-8+,42-15-;;

InChI key

ZCQYZZOGJZASLR-MNBUABMSSA-L

Description

Application

Dy-677 NHS ester, an amine coupling asymmetric cyanine reagent, is used for fluorescent labeling of amine groups within proteins, amino derivatized oligonucleotide and other amine containing molecules.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Lot/Batch Number

1399612

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Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin.

Xiao-Bing Xiong et al.

ACS nano, 5(6), 5202-5213 (2011-06-02)

In this article we report on the development of polymeric micelles that can integrate multiple functions in one system, including the capability to accommodate a combination of therapeutic entities with different physicochemical properties (i.e., siRNA and doxorubicin; DOX), passive and

Controlled modulation of serum protein binding and biodistribution of asymmetric cyanine dyes by variation of the number of sulfonate groups.

Franziska M Hamann et al.

Molecular imaging, 10(4), 258-269 (2011-04-28)

To assess the suitability of asymmetric cyanine dyes for in vivo fluoro-optical molecular imaging, a comprehensive study on the influence of the number of negatively charged sulfonate groups governing the hydrophilicity of the DY-67x family of asymmetric cyanines was performed.

Suitable labels for molecular imaging--influence of dye structure and hydrophilicity on the spectroscopic properties of IgG conjugates.

Jutta Pauli et al.

Bioconjugate chemistry, 22(7), 1298-1308 (2011-05-19)

Aiming at the design of highly brilliant NIR emissive optical probes, e.g., for in vivo near-infrared fluorescence imaging (NIRF), we studied the absorption and fluorescence properties of the asymmetric cyanines Dy678, Dy681, Dy682, and Dy676 conjugated to the model antibody

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Global Trade Item Number

SKU	GTIN
50214-1MG	04061826588390