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Merck
CN

50214

Sigma-Aldrich

Dy-677 NHS ester

suitable for fluorescence

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About This Item

Empirical Formula (Hill Notation):
C47H49N3Na2O14S3
Molecular Weight:
1022.08
MDL number:
MFCD12912384
UNSPSC Code:
12352200
PubChem Substance ID:
329757579
NACRES:
NA.32

Key Documents

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form

solid

fluorescence

λex 666 nm; λem 700 nm in 0.1 M phosphate pH 7.0

suitability

corresponds for coupling to amines
suitable for fluorescence

storage temp.

2-8°C

SMILES string

[Na+].[Na+].CC1=CC(C)(C)N(CCCS([O-])(=O)=O)c2cc3[o+]c(cc(\C=C\C=C4/N(CCCS([O-])(=O)=O)c5ccc(cc5C4(C)CCCC(=O)ON6C(=O)CCC6=O)S([O-])(=O)=O)c3cc12)-c7ccccc7

InChI

1S/C47H51N3O14S3.2Na/c1-31-30-46(2,3)49(23-11-25-66(57,58)59)39-29-41-36(28-35(31)39)33(26-40(63-41)32-12-6-5-7-13-32)14-8-15-42-47(4,21-9-16-45(53)64-50-43(51)19-20-44(50)52)37-27-34(67(60,61)62)17-18-38(37)48(42)22-10-24-65(54,55)56;;/h5-8,12-15,17-18,26-30H,9-11,16,19-25H2,1-4H3,(H2-,54,55,56,57,58,59,60,61,62);;/q;2*+1/p-2/b14-8+,42-15-;;

InChI key

ZCQYZZOGJZASLR-MNBUABMSSA-L

Application

Dy-677 NHS ester, an amine coupling asymmetric cyanine reagent, is used for fluorescent labeling of amine groups within proteins, amino derivatized oligonucleotide and other amine containing molecules.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1399612

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Xiao-Bing Xiong et al.
ACS nano, 5(6), 5202-5213 (2011-06-02)
In this article we report on the development of polymeric micelles that can integrate multiple functions in one system, including the capability to accommodate a combination of therapeutic entities with different physicochemical properties (i.e., siRNA and doxorubicin; DOX), passive and
Franziska M Hamann et al.
Molecular imaging, 10(4), 258-269 (2011-04-28)
To assess the suitability of asymmetric cyanine dyes for in vivo fluoro-optical molecular imaging, a comprehensive study on the influence of the number of negatively charged sulfonate groups governing the hydrophilicity of the DY-67x family of asymmetric cyanines was performed.
Jutta Pauli et al.
Bioconjugate chemistry, 22(7), 1298-1308 (2011-05-19)
Aiming at the design of highly brilliant NIR emissive optical probes, e.g., for in vivo near-infrared fluorescence imaging (NIRF), we studied the absorption and fluorescence properties of the asymmetric cyanines Dy678, Dy681, Dy682, and Dy676 conjugated to the model antibody
Marcia Levitus et al.
Quarterly reviews of biophysics, 44(1), 123-151 (2010-11-27)
The breakthroughs in single molecule spectroscopy of the last decade and the recent advances in super resolution microscopy have boosted the popularity of cyanine dyes in biophysical research. These applications have motivated the investigation of the reactions and relaxation processes
Judith E Berlier et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 51(12), 1699-1712 (2003-11-19)
Amine-reactive N-hydroxysuccinimidyl esters of Alexa Fluor fluorescent dyes with principal absorption maxima at about 555 nm, 633 nm, 647 nm, 660 nm, 680 nm, 700 nm, and 750 nm were conjugated to antibodies and other selected proteins. These conjugates were

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